Seo, Wanji
(2017)
Synthesis and Applications of One- and Two-Dimensional Polymer-Carbon Nanomaterial Composites.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
This dissertation describes the synthesis of polymer and carbon nanomaterial composites and their applications in drug delivery, chemical sensing, and catalytic oxidative patterning. The first part studies polyethylene glycol functionalized oxidized single-walled carbon nanotubes (PLPEG/ox-SWCNT) as a drug nanocarrier to prolong the circulation of two mitochondria targeting radiomitigators TPP-IOA and XJB-5-131. In in vivo tests with mice exposed to a single total body irradiation of 9.25 Gy, the PL-PEG/ox-SWCNT nanocarrier prolongs the circulation of
TPP-IOA without developing apparent toxicity and exhibits radiation mitigating effects, slightly better than that of free TPP-IOA. The in vivo drug effect of the XJB-5-131 conjugate is inconclusive. The stability of Doxorubicin-loaded PL-PEG/ox-SWCNT is investigated under oxidative bursts that occur in neutrophils and macrophages. Myeloperoxidase-catalyzed and peroxynitrite-mediated oxidations of the drug conjugate are studied ex vivo, and the in vitro tests in B16 melanoma cells and tumor-activated myeloid cells are conducted. Both ex vivo and in vitro results indicate that the nanocarrier protects Doxorubicin from the oxidative degradation.
The second part of the dissertation discusses the synthesis and applications of twodimensional
polymers. A novel crystalline polybenzobisimidazole-based two-dimensional supramolecular polymer (2DSP-PBBI) is synthesized by condensation/precipitation
polymerization under solvothermal conditions. The surface morphology of 2DSP-PBBI is analyzed with electron and atomic force microscopy, revealing planar surfaces formed by hydrogen bonding. An iron(III)-coordinated porphyrin-based covalent organic framework (Fe-DhaTph-COF) is synthesized for the fabrication of oxidatively patterned graphite in the presence of H2O2 and/or NaOCl. The vertical channel created by patterning is ~3 nm in depth, and liquidexfoliation of the patterned graphite provides few-layer porous graphene. Although the shape
and size of the pores are not uniform, this study demonstrates that metallated COFs can be
utilized as surface catalysts and master templates for patterning.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
30 January 2017 |
| Date Type: |
Publication |
| Defense Date: |
15 August 2016 |
| Approval Date: |
30 January 2017 |
| Submission Date: |
22 September 2016 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
203 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Polymers, Carbon nanotubes, Graphene, Composites, Oxidation |
| Date Deposited: |
30 Jan 2017 21:08 |
| Last Modified: |
31 Jan 2017 06:15 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/29613 |
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