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Angiogenesis in metastatic colorectal cancer and the benefits of targeted therapy

Sun, W (2012) Angiogenesis in metastatic colorectal cancer and the benefits of targeted therapy. Journal of Hematology and Oncology, 5.

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Abstract

The diverse pathways and molecules involved in angiogenesis, the formation of new blood vessels, have been targeted for the treatment of colorectal and other cancers. Vascular endothelial growth factor (VEGF)-A binding to VEGF receptor (VEGFR)-2 is believed to be the key signaling pathway mediating angiogenesis. Other VEGF pathways involved in angiogenesis include VEGF-A, VEGF-B, and placental growth factor binding to VEGFR-1, and VEGF-C and VEGF-D binding to VEGFR-2 and VEGFR-3. VEGF signaling also intersects with other pathways, including angiopoietin/Tie, Notch, hypoxia-inducible factor, and integrin pathways. The roles of these pathways in tumor angiogenesis and in various human cancers will be explored in this article. In addition, preclinical and clinical data on bevacizumab, aflibercept (known as ziv-aflibercept in the US), and investigational antiangiogenic agents in development for the treatment of colorectal and other cancers will be reviewed. © 2012 Sun; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Sun, Wwes45@pitt.eduWES45
Date: 15 October 2012
Date Type: Publication
Journal or Publication Title: Journal of Hematology and Oncology
Volume: 5
DOI or Unique Handle: 10.1186/1756-8722-5-63
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Article Type: Review
Date Deposited: 30 Nov 2016 17:21
Last Modified: 26 Jan 2019 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/29814

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