NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?

Xiao, G (2012) NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination? Retrovirology, 9.

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Abstract

Activation of the NF-κB transcription factors by the viral protein Tax plays a vital role in the pathogenesis of diseases associated with human T-cell lymphotropic virus type I (HTLV-I). The Tax oncoprotein undergoes constitutive K63-linked ubiquitination and sumoylation; however, the roles and molecular mechanisms of these post-translational modifications in Tax-mediated NF-κB activation are being debated. Here, we discuss our current understanding of Tax activation of NF-κB, with a focus on the controversies and the challenges that we are facing. © 2012 Xiao; licensee BioMed Central Ltd.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Xiao, G gux8@pitt.edu GUX8
Centers:	Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date:	25 September 2012
Date Type:	Publication
Journal or Publication Title:	Retrovirology
Volume:	9
DOI or Unique Handle:	10.1186/1742-4690-9-78
Schools and Programs:	School of Medicine > Microbiology and Molecular Genetics
Refereed:	Yes
Date Deposited:	11 Oct 2016 18:31
Last Modified:	24 Jan 2019 00:55
URI:	http://d-scholarship.pitt.edu/id/eprint/29827

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