The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease

Antúnez, C and Boada, M and González-Pérez, A and Gayán, J and Ramírez-Lorca, R and Marín, J and Hernández, I and Moreno-Rey, C and Morón, FJ and López-Arrieta, J and Mauleón, A and Rosende-Roca, M and Noguera-Perea, F and Legaz-García, A and Vivancos-Moreau, L and Velasco, J and Carrasco, JM and Alegret, M and Antequera-Torres, M and Manzanares, S and Romo, A and Blanca, I and Ruiz, S and Espinosa, A and Castaño, S and García, B and Martínez-Herrada, B and Vinyes, G and Lafuente, A and Becker, JT and Galán, JJ and Serrano-Ríos, M and Ruiz, and Vázquez, E and Tárraga, L and Sáez, ME and López, OL and Real, LM and Ruiz, A (2011) The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. Genome Medicine, 3 (5).

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Abstract

Background: In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population.Methods: We genotyped 1,128 individuals using the Affymetrix Nsp I 250K chip. A sample of 327 sporadic AD patients and 801 controls with unknown cognitive status from the Spanish general population were included in our initial study. To increase the power of the study, we combined our results with those of four other public GWAS datasets by applying identical quality control filters and the same imputation methods, which were then analyzed with a global meta-GWAS. A replication sample with 2,200 sporadic AD patients and 2,301 controls was genotyped to confirm our GWAS findings.Results: Meta-analysis of our data and independent replication datasets allowed us to confirm a novel genome-wide significant association of AD with the membrane-spanning 4-domains subfamily A (MS4A) gene cluster (rs1562990, P = 4.40E-11, odds ratio = 0.88, 95% confidence interval 0.85 to 0.91, n = 10,181 cases and 14,341 controls).Conclusions: Our results underscore the importance of international efforts combining GWAS datasets to isolate genetic loci for complex diseases. © 2011 Antúnez et al.; licensee BioMed Central Ltd.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Antúnez, C Boada, M González-Pérez, A Gayán, J Ramírez-Lorca, R Marín, J Hernández, I Moreno-Rey, C Morón, FJ López-Arrieta, J Mauleón, A Rosende-Roca, M Noguera-Perea, F Legaz-García, A Vivancos-Moreau, L Velasco, J Carrasco, JM Alegret, M Antequera-Torres, M Manzanares, S Romo, A Blanca, I Ruiz, S Espinosa, A Castaño, S García, B Martínez-Herrada, B Vinyes, G Lafuente, A Becker, JT BECKERJT@pitt.edu BECKERJT Galán, JJ Serrano-Ríos, M Ruiz, Vázquez, E Tárraga, L Sáez, ME López, OL Real, LM Ruiz, A
Centers:	Other Centers, Institutes, Offices, or Units > Alzheimer's Disease Research Center
Date:	31 May 2011
Date Type:	Publication
Journal or Publication Title:	Genome Medicine
Volume:	3
Number:	5
DOI or Unique Handle:	10.1186/gm249
Schools and Programs:	Dietrich School of Arts and Sciences > Psychology School of Medicine > Neurology School of Medicine > Psychiatry
Refereed:	Yes
Date Deposited:	27 Oct 2016 19:29
Last Modified:	11 Jan 2021 11:55
URI:	http://d-scholarship.pitt.edu/id/eprint/30054

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