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Hypothermia, immune suppression and SDD: Can we have our cake and eat it?

Polderman, KH (2011) Hypothermia, immune suppression and SDD: Can we have our cake and eat it? Critical Care, 15 (2). ISSN 1364-8535

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Abstract

In vitro studies and clinical observations suggest that both accidental and controlled/therapeutic hypothermia have a strong immunosuppressive effect, and that hypothermia increases the risk of infections, especially wound infections and pneumonia. In the previous issue of Critical Care, Kamps and colleagues report that when hypothermia was used for prolonged periods in patients with severe traumatic brain injury in conjunction with selective decontamination of the digestive tract, the risks of infection were the same or lower in patients treated with therapeutic cooling. The risk of infection is widely regarded as the most important danger of therapeutic cooling. The findings of Kamps and colleagues need to be verified in prospective trials and in higher-resistance environments, but raise the possibility of cooling for prolonged periods with greatly reduced risk. We may be able to have our cake and eat it. © 2011 BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Polderman, KHkhp5@pitt.eduKHP5
Date: 31 March 2011
Date Type: Publication
Journal or Publication Title: Critical Care
Volume: 15
Number: 2
DOI or Unique Handle: 10.1186/cc10080
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 1364-8535
Date Deposited: 31 Oct 2016 16:05
Last Modified: 05 Feb 2019 11:55
URI: http://d-scholarship.pitt.edu/id/eprint/30077

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