Hayashi, D and Roemer, FW and Dhina, Z and Kwoh, CK and Hannon, MJ and Moore, C and Guermazi, A
(2010)
Longitudinal assessment of cyst-like lesions of the knee and their relation to radiographic osteoarthritis and MRI-detected effusion and synovitis in patients with knee pain.
Arthritis Research and Therapy, 12 (5).
ISSN 1478-6354
Abstract
Introduction: The purpose of the present study was to determine the prevalence of cystic lesions and cyst-like bursitides in subjects with frequent knee pain and to assess their relation to radiographic osteoarthritis (OA) severity; to describe bilaterality and size fluctuation of the lesions over 6 months; and to assess relations between the prevalence of synovium-lined lesions communicating with the joint capsule and severity of magnetic resonance imaging (MRI)-detected effusion and synovitis.Methods: One hundred and sixty-three subjects (total 319 knees) aged 35 to 65 with chronic, frequent knee pain were included. Imaging with 3 Tesla MRI was performed at baseline and 6-month follow-up with the same protocols as those used in the Osteoarthritis Initiative. Severity of radiographic OA was assessed using the Kellgren-Lawrence grade (0 to 4). Severity of effusion and synovitis was graded 0 to 3 based on the Whole Organ Magnetic Resonance Imaging Score system. The associations of cysts and cyst-like bursitides and severity of radiographic OA, MRI-detected effusion and synovitis were analyzed using logistic regression controlling for clustering by person. The Wilcoxon signed-rank test was used to determine whether there was a significant change in the size of lesions between baseline and follow-up.Results: At least one lesion (any type) was present in 222 (70%) knees. The most prevalent lesions were popliteal cysts (40%, 128/319), followed by subgastrocnemius bursitis (15%, 49/319) and proximal tibiofibular joint cysts (8%, 26/319). Bilateral lesions were seen in 49% of the subjects. Only popliteal cysts and subgastrocnemius bursitis showed a significant change in size (P < 0.001). No trend was observed between prevalence of any of the cyst-like lesions analyzed and the increasing radiographic OA severity. Increasing prevalence of subgastrocnemius bursitis was associated with increasing severity of effusion (P = 0.0072) and synovitis (P = 0.0033).Conclusions: None of the cyst-like lesions analyzed seems to be a marker of radiographic OA severity in knees with chronic frequent pain. Subgastrocnemius bursitis may be used as a marker of effusion/synovitis severity. Bilateral cyst-like lesions are relatively commonly observed in people with chronic knee pain. © 2010 Hayashi et al.; licensee BioMed Central Ltd.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Hayashi, D | | | | Roemer, FW | | | | Dhina, Z | | | | Kwoh, CK | | | | Hannon, MJ | mjh58@pitt.edu | MJH58 | | Moore, C | | | | Guermazi, A | | | |
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Date: |
15 September 2010 |
Date Type: |
Publication |
Journal or Publication Title: |
Arthritis Research and Therapy |
Volume: |
12 |
Number: |
5 |
DOI or Unique Handle: |
10.1186/ar3132 |
Schools and Programs: |
School of Medicine > Immunology |
Refereed: |
Yes |
ISSN: |
1478-6354 |
Date Deposited: |
14 Nov 2016 17:40 |
Last Modified: |
03 Feb 2019 04:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/30240 |
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