Verification of a novel rabbit model used in the study of human intracranial aneurysm

Yang, Qi (2017) Verification of a novel rabbit model used in the study of human intracranial aneurysm. Master's Thesis, University of Pittsburgh. (Unpublished)

	Image (JPEG) Download (21kB)
	Image (JPEG) Download (36kB)
	Image (JPEG) Download (22kB)
	Image (JPEG) Download (20kB)
	Image (PNG) Download (43kB)
	Image (PNG) Download (24kB)
	Image (JPEG) Download (21kB)
	Image (JPEG) Download (21kB)
	Image (JPEG) Download (14kB)
	Image (JPEG) Download (69kB)
	Image (JPEG) Download (35kB)
	Image (JPEG) Download (22kB)
	Image (JPEG) Download (38kB)
	Image (JPEG) Download (71kB)
	Image (PNG) Download (7kB)
Preview	PDF Download (829kB) | Preview

Abstract

Coupling the hemodynamics with the pathophysiology of human intracranial aneurysm (IA) has been a subject of interest for eventually obtaining the reliable prediction of subarachnoid hemorrhage caused by aneurysm rupture. In recent works, the stability of flow patterns, regions of impingement, size of jets, wall shear stress (WSS), and the formation of vortices are considered to be the major causes of aneurysm rupture. A trending conclusion from the qualitative analysis of patient-specific cases is that aneurysms with simple stable flow patterns and large impingement region are safer than those with complex unstable flow pattern and small impingement region. When it comes to clinic, some physical experiments such as the testing of medical devices could not be operated on human body. Thus, preclinical animal models are introduced as surrogates. In the study of human IA, the most commonly used elastase-induced rabbit model has been found that it could only generate limited flow pattern due to the unrealistic retrograde flow condition inside the aneurysm. A novel method of creating bifurcation-like rabbit model for limiting retrograde flow was proposed recently and two new bifurcation-like rabbit aneurysms with different geometry were created in Mayo clinic. However, only the performance of the one with relative generalized geometry was testified. In this paper, the other novel bifurcation-like rabbit aneurysm model with irregular long sac was investigated and its hemodynamics performance has been extensively evaluated by using computational fluid dynamic (CFD) method. The methodology of creating this rabbit aneurysm model, the construction of geometric model in the computer and the setting of boundary conditions will be described in detail. The robustness of this rabbit model has also been investigated by modifying the essential geometric variables of the model. Additionally, quantitative analysis of flow pattern changes was given as supplement for the robustness study. The result showed that this rabbit model with irregular long sac is capable of generating interest-relevant flow types and robust enough under geometric perturbation. It could serve as an extra evidence that the novel bifurcation-like rabbit model is powerful and robust enough for extrapolating results of animal experiments into human study.

---

Share

Citation/Export:	Select format... Citation - Text Citation - HTML Endnote BibTex Dublin Core OpenURL MARC (ISO 2709) METS MODS EP3 XML Reference Manager Refer
Social Networking:	Share |

---

Details

Item Type:	University of Pittsburgh ETD
Status:	Unpublished
Creators/Authors:	Creators Email Pitt Username ORCID Yang, Qi qiy20@pitt.edu qiy20 0000-0003-1373-8373
ETD Committee:	Title Member Email Address Pitt Username ORCID Thesis Advisor Robertson, Anne Anne.Robertson@pitt.edu Committee Member Galdi, Giovanni Paolo galdi@pitt.edu Committee Member Cho, Sung Kwon skcho@pitt.edu
Date:	6 March 2017
Defense Date:	4 April 2017
Approval Date:	13 June 2017
Submission Date:	28 March 2017
Access Restriction:	No restriction; Release the ETD for access worldwide immediately.
Number of Pages:	63
Institution:	University of Pittsburgh
Schools and Programs:	Swanson School of Engineering > Mechanical Engineering and Materials Science
Degree:	MS - Master of Science
Thesis Type:	Master's Thesis
Refereed:	Yes
Uncontrolled Keywords:	human intracranial aneurysm, rabbit model, CFD
Date Deposited:	13 Jun 2017 17:53
Last Modified:	13 Jun 2017 17:53
URI:	http://d-scholarship.pitt.edu/id/eprint/31070

Available Versions of this Item

• Verification of a novel rabbit model used in the study of human intracranial aneurysm. (deposited 13 Jun 2017 17:53) [Currently Displayed]

---

Metrics

Monthly Views for the past 3 years

Plum Analytics

---

Actions (login required)

View Item