Patil, Avinash
(2017)
SELF-ASSEMBLED ALKYLSILANE COATINGS FOR RESORBABLE
BIOMEDICAL DEVICES.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
This is the latest version of this item.
Abstract
Magnesium (Mg) and its alloys are excellent candidate materials for resorbable biomedical
devices. They are lightweight, biocompatible, osteoinductive and have mechanical properties
similar to bone. Most importantly, they can degrade in the body, eliminating the need for device
removal surgeries, thus reducing potential complications, patient pain and suffering, and
relieving the burden on the healthcare system. The major roadblock for wide implementation of
Mg implantable devices is the initial rapid corrosion of the devices, which causes formation of
gas pocket around the implant. This can impede healing. One strategy to overcome this problem
is use of anticorrosion coatings. We have developed alkylsilane (AS) self-assembled multilayer
coatings to control Mg corrosion, increase the biocompatibility of Mg and be further
functionalized with bioactive molecules. AS coatings are formed by copolymerization of n-
Decyltriethoxysilane and Tetramethoxysilane followed by a dip coating of Mg discs. Some of
them were further functionalized with (3-Aminopropyl) triethoxysilane. Structural, chemical and
anticorrosive properties of the AS coatings were assessed by numerous characterization
techniques. The resulting coatings comprised of highly homogeneous 1 mm thin layers that
significantly reduced corrosion in vitro and in vivo. In vitro and in vivo studies demonstrated the
coating’s high cytocompatibility and low toxicity. Furthermore, the in vivo studies demonstrated
that AS coatings could slow gas bubble formation around implanted Mg devices. Overall, our
study demonstrates that AS coatings can be used to control corrosion of resorbable Mg devices.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
| Title | Member | Email Address | Pitt Username | ORCID |
|---|
| Committee Chair | Beniash, Elia | ebeniash@pitt.edu | | | | Committee Member | Sfeir, Charles | | | | | Committee Member | Kumta, Prashant | | | | | Committee Member | Tracy Cui, Xinyan | | | | | Committee Member | Gawalt, Ellen | | | |
|
| Date: |
26 September 2017 |
| Date Type: |
Publication |
| Defense Date: |
19 June 2017 |
| Approval Date: |
26 September 2017 |
| Submission Date: |
26 July 2017 |
| Access Restriction: |
1 year -- Restrict access to University of Pittsburgh for a period of 1 year. |
| Number of Pages: |
144 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Swanson School of Engineering > Bioengineering |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Magnesium, AZ31, resorbable, implant, alkylsilane, coating, corrosion, self-assembly, cytocompatibility |
| Date Deposited: |
26 Sep 2018 05:00 |
| Last Modified: |
26 Sep 2018 05:15 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/32930 |
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