Park, Sohyun
(2017)
Efficacy of Platelet-Rich Fibrin on Wound Healing and Pain following Guided Bone Regeneration.
Master's Thesis, University of Pittsburgh.
(Unpublished)
This is the latest version of this item.
Abstract
Purpose: The purpose of this study was to evaluate the effect of platelet-rich fibrin (PRF) on the soft tissue wound healing and postoperative pain when it is used as an adjunct therapy for guided bone regeneration (GBR) procedures.
Materials and Methods: Seven patients were randomly assigned to test group (GBR + PRF; n=5) and control group (GBR only; n=2), and soft tissue healing and pain levels were evaluated. Routine GBR procedures using dPTFE membranes were performed for control group. For the test group, the liquid-form PRF was mixed with bone graft materials and PRF membranes were placed on top of the dPTFE membrane. Following surgery, patients in both groups were given a visual analog scale (100 mm) to use for rating their pain level every night for the next week. Post-operative appointments were scheduled at weeks 1, 2, 4, 6, 8, 12, and 16. During the post-operative appointments, the soft tissue healings were evaluated. The present report follows patients for the first 6 weeks post-GBR surgery.
Results: Patients in the test group showed a more rapid decline in self-reported pain, with ratings for the test group being substantially lower than those for the control group. Whereas no membrane exposure was noted for either control patient, exposure was noted for two of the five test patients during follow-up visits. In contrast to membrane exposure, evidence of gingival inflammation was noted in all patients. Similar to the findings for membrane exposure, abnormality in soft tissue consistency was noted for participants in the test group only, mainly in the exposure patients.
Conclusion: The present study suggests that addition of PRF to GBR procedures may lower the postoperative pain level. But due to the small sample size, it was difficult to draw a conclusion on the effect of PRF on the membrane exposure and other soft tissue parameters. After additional data are collected by the next investigator, we may be able to draw more definitive conclusions. The next report will also look at the bone quality and quantity in the histologic and radiographic analysis.
Share
| Citation/Export: |
|
| Social Networking: |
|
Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID  |
|---|
| Committee Chair | Williams, Kelly | KellyWilliams@pitt.edu | UNSPECIFIED | UNSPECIFIED | | Committee Member | Kumar, Satish | satish.kumar@pitt.edu | UNSPECIFIED | UNSPECIFIED | | Committee Member | Potluri, Anitha | anp60@pitt.edu | UNSPECIFIED | UNSPECIFIED | | Committee Member | Ray, Herbert | hlr21@pitt.edu | UNSPECIFIED | UNSPECIFIED |
|
| ETD Committee: |
|
| Date: |
7 August 2017 |
| Defense Date: |
11 July 2017 |
| Approval Date: |
17 August 2017 |
| Submission Date: |
11 August 2017 |
| Access Restriction: |
3 year -- Restrict access to University of Pittsburgh for a period of 3 years. |
| Number of Pages: |
50 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Dental Medicine > Dental Science |
| Degree: |
MDS - Master of Dental Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
No |
| Uncontrolled Keywords: |
PRF, platelet-rich fibrin, GBR, guided bone regeneration, nonresorbable membrane, dPTFE, pain, soft tissue healing, membrane exposure, Bio-Oss |
| Article Type: |
Research Article |
| Date Deposited: |
17 Aug 2017 19:47 |
| Last Modified: |
17 Aug 2020 05:15 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/33113 |
Available Versions of this Item
-
Efficacy of Platelet-Rich Fibrin on Wound Healing and Pain following Guided Bone Regeneration. (deposited 17 Aug 2017 19:47)
[Currently Displayed]
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
 |
View Item |
![[feed]](/images/feed-icon-32x32.png){kind=icon}