Lypson, Alyssa B.
(2018)
Synthesis of the Conformationally Controlled β–Turn Mimetic Torsion Balance Core Scaffold.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
The molecular torsion balance concept was applied to a new conformationally controlled scaffold to accurately evaluate pairwise amino acid interactions in an antiparallel β-sheet motif. The scaffold’s core design combines (ortho-tolyl)amide and o,o,o′-trisubstituted biphenyl structural units to provide a geometry better-suited for intramolecular hydrogen bonding. The aim of this study was to develop synthetic methods for the core scaffold and to conduct a preliminary investigation into the improved sequence alignment on upper and lower aromatic rings to promote hydrogen bond formation at the correct distance and antiparallel orientation.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
14 June 2018 |
| Date Type: |
Publication |
| Defense Date: |
5 January 2018 |
| Approval Date: |
14 June 2018 |
| Submission Date: |
3 April 2018 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
100 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
torsion balance, peptidomimetic, β-sheet, synthesis, NMR |
| Date Deposited: |
14 Jun 2018 13:31 |
| Last Modified: |
13 Mar 2019 18:37 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/33990 |
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