An, Yunqi
(2018)
The Role of Sulfotransferase 2B1b in Acetaminophen-induced Liver injury.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Overdose of acetaminophen (APAP) is the leading cause of acute liver failure (ALF). Although mechanisms of APAP-induced liver injury are well known, those that affect the progression of APAP-induced liver disease and facilitate liver recovery are less understood. The sulfotransferase 2B1b (SULT2B1b) participates various of liver relative diseases including metabolic syndrome, chronic liver injury and hepatocellular carcinoma. Our previous study showed that SULT2B1b is transcriptional regulated by Hepatic Nuclear Factor 4α (HNF4α), which is essential for liver development and function. However, the importance of SULT2B1b in APAP-induced acute liver injury remains unknown. In this study, we examined the role of SULT2B1b in APAP-induced hepatotoxicity. We showed that hepatic overexpression of SULT2B1b in liver sensitized mice to APAP-induced liver injury, whereas ablation of Sult2B1b conferred resistance to the APAP hepatotoxicity. Indeed, upregulation of Sult2B1b by Hnf4α in wild type mice showed more severe liver injury and this effect was abolished in Sult2B1b knockout mice evidenced by comparable liver damage. Therefore, we conclude that SULT2B1b represents a potential therapeutic target for the prevention and treatment of APAP-induced acute liver injury.
Share
| Citation/Export: |
|
| Social Networking: |
|
Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
9 April 2018 |
| Date Type: |
Publication |
| Defense Date: |
14 March 2018 |
| Approval Date: |
9 April 2018 |
| Submission Date: |
5 April 2018 |
| Access Restriction: |
1 year -- Restrict access to University of Pittsburgh for a period of 1 year. |
| Number of Pages: |
39 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Pharmacy > Pharmaceutical Sciences |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
sulfotransferase; HNF4α; acetaminophen; liver injury |
| Date Deposited: |
09 Apr 2018 15:12 |
| Last Modified: |
09 Apr 2019 05:15 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/34117 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
 |
View Item |
![[feed]](/images/feed-icon-32x32.png){kind=icon}