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The comparative in vitro and in vivo activity of antilymphocyte serum raised by immunization with thymic, splenic, and lymph node lymphocytes

Ono, K and Bell, P and Kashiwagi, N and Starzl, TE (1969) The comparative in vitro and in vivo activity of antilymphocyte serum raised by immunization with thymic, splenic, and lymph node lymphocytes. Surgery, 66 (4). 698 - 703. ISSN 0039-6060

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Abstract

Rabbit ALS was raised against the splenic, thymic, and lymph node lymphocytes of inbred Fischer rats. The different antisera had the same ability to induce lymphopenia or to protect auxiliary cardiac homografts from rejection after transplantation from Wistar-Furth donors to Fischer recipients. There was a difference in the toxicity of the agents in that the antispleen and antithymus sera caused thrombocytopenia. The severity of this complication seemed related to the degree of platelet contamination of the rat cell suspensions originally given to the rabbits. The thrombocytopenia can be at least partially avoided by cleaning up the immunizing antigen as well as by platelet absorption of the resulting ALS. © 1969.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ono, K
Bell, P
Kashiwagi, N
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 October 1969
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 66
Number: 4
Page Range: 698 - 703
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062125210, Starzl CV No. 195
PubMed ID: 4898466
Date Deposited: 08 Apr 2010 17:03
Last Modified: 13 Oct 2017 16:55
URI: http://d-scholarship.pitt.edu/id/eprint/3581

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