Suway, Steven B
(2019)
Neural State Changes in Primate Motor Cortex During Arm Movements with Distinct Control Requirements.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
The primary motor cortex (M1) is an important structure of the motor system that contributes to
many aspects of movement. Firing patterns of M1 neurons can be surprisingly complex, and there
is substantial interest in understanding these patterns and their relation to behavior. Here, we
characterize the temporal structure of M1 activity during reaching in several ways. First, we show
that single neurons encode movement information in a series of discrete segments. Information is
stably encoded during each brief segment, and the firing patterns of most neurons transition
between segments at similar times during movement. This pattern may therefore reflect transitions
between different neural “states.” Next, we establish that the sequence of states observed during
behavior is related to a sequence of distinct drivers, including visuospatial information and visual
feedback from a movement. If no feedback is provided, neurons may produce a truncated response
sequence. Last, we link the temporal structure of firing patterns to the structure of reaches and
demonstrate that the classical two-component model of reaching is reflected in M1 activity. Our
findings may help establish a useful framework for interpreting seemingly complex neural activity
during behavior.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
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| Date: |
5 March 2019 |
| Date Type: |
Publication |
| Defense Date: |
23 January 2019 |
| Approval Date: |
5 March 2019 |
| Submission Date: |
11 February 2019 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
199 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Medicine > Neurobiology |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
motor systems; motor cortex; multi-electrode array; macaque; reaching; neural states; neural encoding |
| Date Deposited: |
05 Mar 2019 19:47 |
| Last Modified: |
05 Mar 2019 19:47 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/35968 |
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