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Defining the Placental Barrier during Toxoplasma gondii Infection

Ander, Stephanie E (2019) Defining the Placental Barrier during Toxoplasma gondii Infection. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

Toxoplasma gondii is a major source of congenital disease worldwide, but the cellular and molecular factors associated with its vertical transmission are largely unknown. In humans, the placenta forms the key interface between the maternal and fetal compartments and forms the primary barrier that restricts the hematogenous spread of microorganisms. This dissertation describes both the identification of two mechanisms of placental syncytiotrophoblast resistance to T. gondii infection and a preliminary understanding of the CCL22 response induced by the Toxoplasma dense granule protein GRA28. Collectively, these findings provide new insights into (1) protective role of the syncytiotrophoblast during T. gondii infection, (2) interferon-gamma independent restriction of T. gondii growth, and (3) parasite-directed manipulation of the intercellular communication between the placenta and components of the maternal immune system.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ander, Stephanie Esta23@pitt.edusta23
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairCoyne, Carolyncoynec2@pitt.edu
Committee MemberBoyle, Jonboylej@pitt.edu
Committee MemberBomberger, Jenniferjbomb@pitt.edu
Committee MemberGaffen, Sarahsarah.gaffen@pitt.edu
Committee MemberSadovsky, Yoelysadovsky@mwri.magee.edu
Date: 17 April 2019
Date Type: Publication
Defense Date: 5 March 2019
Approval Date: 17 April 2019
Submission Date: 26 March 2019
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 151
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Microbiology and Immunology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: T. gondii Toxoplasma placenta trophoblast syncytiotrophoblast GRA28 CCL22
Date Deposited: 17 Apr 2019 14:52
Last Modified: 17 Apr 2020 05:15
URI: http://d-scholarship.pitt.edu/id/eprint/36438

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