Huffer, WE and Kuzela, D and Popovtzer, MM and Starzl, TE
(1975)
Metabolic bone disease in chronic renal failure. II. Renal transplant patients.
Am J Pathol, 78 (3).
385 - 400.
ISSN 0002-9440
Abstract
Trabecular vertebral bone of renal transplant patients was quantitatively compared with bone from normal individuals and dialyzed and nondialyzed patienets with chronic renal failure reported in detail in an earlier study. Long- and short-term transplant patients have increased bone resorption and mineralization defects similar to renal osteodystrophy in dialyzed and nondialyzed patients. However, in transplant patients the magnitude of resorption is greater, and bone volume tends to decrease rather than increase. Resorptive activity in transplant patients is maximal during the first year after transplantation. Bone volume decreases continuously for at least 96 months after transplantation. Only decreased bone volume correlated with success or failure of the renal transplant. Morphologic findings in this study correlate with other clinical and morphologic data to suggest that reduction in bone volume in transplant patients results from a combination of persistent hyperparathyroidism and suppression of bone formation by steroid therapy.
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Details
| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Huffer, WE | | | | | Kuzela, D | | | | | Popovtzer, MM | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
March 1975 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Am J Pathol |
| Volume: |
78 |
| Number: |
3 |
| Page Range: |
385 - 400 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Adult, Bone Diseases, Bone Resorption, Graft Rejection, Humans, Kidney Failure, Chronic, Kidney Transplantation, Lumbar Vertebrae, Middle Aged, Minerals, Osteoporosis, Renal Dialysis, Time Factors, Transplantation, Homologous |
| ISSN: |
0002-9440 |
| Other ID: |
uls-drl:31735062109404, Starzl CV No. 338 |
| Date Deposited: |
08 Apr 2010 17:05 |
| Last Modified: |
05 Dec 2017 17:00 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/3724 |
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