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DIVERGENT NEURAL PATHWAYS EMANATING FROM THE LATERAL PARABRACHIAL NUCLEUS MEDIATE DISTINCT COMPONENTS OF THE PAIN RESPONSE

Chiang, Michael (2019) DIVERGENT NEURAL PATHWAYS EMANATING FROM THE LATERAL PARABRACHIAL NUCLEUS MEDIATE DISTINCT COMPONENTS OF THE PAIN RESPONSE. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

The lateral parabrachial nucleus (lPBN) is a major target of spinal projection neurons conveying nociceptive input into supraspinal structures. However, the functional role of distinct lPBN efferents for diverse nocifensive responses have remained largely uncharacterized. Here, we show that two populations of efferent neurons from different regions of the lPBN collateralize to distinct targets. Activation of efferent projections to the ventromedial hypothalamus (VMH) or lateral periaqueductal gray (lPAG) drive escape behaviors, whereas the activation of lPBN efferents to the bed nucleus stria terminalis (BNST) or central amygdala (CEA) generates an aversive memory. Finally, we provide evidence that dynorphin expressing neurons span cytoarchitecturally distinct domains of the lPBN to coordinate these distinct aspects of the nocifensive response.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chiang, Michaelmic78@pitt.edumic78@pitt.edu
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairSeal, Rebeccarpseal@pitt.edu
Thesis AdvisorRoss, Sarahsaross@pitt.edu
Committee MemberGold, Michaelmsg22@pitt.edu
Committee MemberUrban, Nathanielnurban@pitt.edu
Committee MemberHooks, Bryanhooksm@pitt.edu
Committee MemberSaper, Cliffordcsaper@bidmc.harvard.edu
Date: 13 September 2019
Date Type: Publication
Defense Date: 12 July 2019
Approval Date: 13 September 2019
Submission Date: 19 July 2019
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 161
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Neurobiology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Lateral parabrachial nucleus; lPBN; pain; mouse; dynorphin; BNST; CEA; VMH; lPAG; bed nucleus stria terminalis; central amygdala; ventromedial hypothalamus; lateral periaqueductal gray; aversion; escape; NK1R; neurokinin 1 receptor; nociception; optogenetics; midbrain
Date Deposited: 13 Sep 2019 14:22
Last Modified: 17 Sep 2019 16:40
URI: http://d-scholarship.pitt.edu/id/eprint/37297

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