Cyclosporin a hepatotoxicity in 66 renal allograft recipients

Klintmalm, GBG and Iwatsuki, S and Starzl, TE (1981) Cyclosporin a hepatotoxicity in 66 renal allograft recipients. Transplantation, 32 (6). 488 - 489. ISSN 0041-1337

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Abstract

Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. However, such presumed hepatotoxicity was a minor problem in the use of cyclosporin A. The complication was less frequent than that of nephrotoxicity, was as easily manageable with reductions in the cyclosporin A dosage, and generally did not cause clinical illness. In an occasional case, late hepatotoxicity can force a therapeutic change from cyclosporin A to azathioprine, but careful consideration should be given to the dangers of subsequent rejection. © 1981 by The Williams and Wilkins Co.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Klintmalm, GBG Iwatsuki, S Starzl, TE tes11@pitt.edu TES11
Centers:	Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date:	1 January 1981
Date Type:	Publication
Journal or Publication Title:	Transplantation
Volume:	32
Number:	6
Page Range:	488 - 489
DOI or Unique Handle:	10.1097/00007890-198112000-00007
Institution:	University of Pittsburgh
Refereed:	Yes
ISSN:	0041-1337
Other ID:	uls-drl:31735062114404, Starzl CV No. 472
Date Deposited:	08 Apr 2010 17:08
Last Modified:	02 Feb 2019 13:55
URI:	http://d-scholarship.pitt.edu/id/eprint/3858

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