Klintmalm, GB and Klingensmith, WC and Iwatsuki, S and Schröter, GP and Starzl, TE
(1982)
99mTc-DTPA and 131I-hippuran findings in liver transplant recipients treated with cyclosporin A.
Radiology, 142 (1).
199 - 202.
ISSN 0033-8419
Abstract
The effects of cyclosporin A (CyA), an immunosuppressive agent that is potentially nephrotoxic, on the kidneys of 9 liver transplant recipients were studied with serial 99mTc-DTPA and 131I-hippuran scans. In addition, renal function was determined by measuring serum creatinine levels during the second postoperative week in the 9 unselected CyA-treated patients and, retrospectively, in a control group of 29 liver transplant recipients who had not been treated with CyA and who were selected because they had survived for at least 3 months postoperatively. The early postoperative creatinine level was significantly greater in the CyA group. Eight of the 9 CyA patients showed imaging abnormalities in all preoperative and postoperative studies. Five of the 8 patients showed a pattern similar to that of acute tubular necrosis (relatively preserved perfusion) in at least one study. Lowering the dosage of CyA permitted the continuation of therapy, and all 9 patients are alive after 8 to 14 months.
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Details
| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Klintmalm, GB | | | | | Klingensmith, WC | | | | | Iwatsuki, S | | | | | Schröter, GP | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
January 1982 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Radiology |
| Volume: |
142 |
| Number: |
1 |
| Page Range: |
199 - 202 |
| DOI or Unique Handle: |
10.1148/radiology.142.1.7031760 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Bilirubin, Creatinine, Cyclosporins, Humans, Iodohippuric Acid, Kidney, Liver Transplantation, Pentetic Acid, Postoperative Period, Radionuclide Imaging, Technetium, Technetium Tc 99m Pentetate |
| ISSN: |
0033-8419 |
| Funders: |
NIDDK NIH HHS (R01 AM007772), NIADDK NIH HHS (R01 AM007772) |
| Other ID: |
uls-drl:31735062114420, Starzl CV No. 478 |
| Date Deposited: |
08 Apr 2010 17:08 |
| Last Modified: |
05 Dec 2017 17:00 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/3864 |
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