REVERSAL OF HEPATIC ALPHA-1-ANTITRYPSIN DEPOSITION AFTER PORTACAVAL SHUNT

Starzl, TE and Francavilla, A and Porter, KA and Iwatsuki, S (1983) REVERSAL OF HEPATIC ALPHA-1-ANTITRYPSIN DEPOSITION AFTER PORTACAVAL SHUNT. The Lancet, 322 (8347). 424 - 426. ISSN 0140-6736

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Abstract

End-to-side portacaval shunts were carried out in three children with the liver disease of alpha-1-antitrypsin deficiency and complications of portal hypertension. Their clinical courses have been stable for 31/2 to almost 7 years. Postoperative liver biopsy material from two of the patients showed the typical histopathological changes caused by portal diversion, as well as an apparent reduction in the quantity of alpha-1-antitrypsin particles in the hepatocytes. The metabolic changes caused by portal diversion have apparently created a more favourable equilibrium between the synthesis and excretion of the abnormal alpha-1-antitrypsin. © 1983.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Starzl, TE tes11@pitt.edu TES11 Francavilla, A Porter, KA Iwatsuki, S
Centers:	Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date:	20 August 1983
Date Type:	Publication
Journal or Publication Title:	The Lancet
Volume:	322
Number:	8347
Page Range:	424 - 426
DOI or Unique Handle:	10.1016/s0140-6736(83)90390-2
Institution:	University of Pittsburgh
Refereed:	Yes
ISSN:	0140-6736
Other ID:	uls-drl:31735062114875, Starzl CV No. 521
PubMed ID:	6135912
Date Deposited:	08 Apr 2010 17:08
Last Modified:	14 Oct 2017 10:55
URI:	http://d-scholarship.pitt.edu/id/eprint/3907

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