Peasley, Kevin
(2020)
Sirtuins in Kidney Injury and Disease.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Acute kidney injury (AKI) is an extremely common medical affliction resulting from hypoxic, nephrotoxic and septic insults affecting approximately 20% of all hospital patients and up to 50% of patients in the intensive care unit. There are currently no therapeutics for patients that suffer AKI. Much recent work has focused on designing and implementing therapeutics for AKI. The sirtuins are a family of enzymes that play critical roles in regulating many cellular and biological functions. There are 7 mammalian sirtuins (Sirt1-7) that are known to regulate the acylation of a wide variety of pathways. Furthermore, all but one of the mammalian sirtuins have been shown to be important in mediating AKI based on preclinical studies. These diverse enzymes show exciting potential for therapeutic manipulation. While considerable research has been done on SIRT1 and its role in the kidney, much less is known about mitochondrial SIRT5 in the context of AKI. My research has strove to elucidate the role of SIRT5 in acute kidney injury through in vivo mouse studies and in vitro means with a particular focus on its function as a regulator of fatty acid oxidation.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
29 September 2020 |
| Date Type: |
Publication |
| Defense Date: |
21 August 2020 |
| Approval Date: |
29 September 2020 |
| Submission Date: |
21 August 2020 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
45 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Medicine > Molecular Genetics and Developmental Biology |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Sirtuins, Acute Kidney Injury, AKI, Metabolism |
| Date Deposited: |
29 Sep 2020 23:37 |
| Last Modified: |
29 Sep 2020 23:37 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/39663 |
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