Du, Wenwen and Yang, Min and Turner, Abbey and Xu, Chunling and Ferris, Robert and Huang, Jianan and Kane, Lawrence and Lu, Binfeng
(2017)
TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action.
International Journal of Molecular Sciences, 18 (3).
ISSN 1422-0067
Abstract
Cancer immunotherapy has produced impressive clinical results in recent years. Despite the success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death receptor 1 (PD-1), a large portion of cancer patients have not yet benefited from this novel therapy. T cell immunoglobulin and mucin domain 3 (TIM-3) has been shown to mediate immune tolerance in mouse models of infectious diseases, alloimmunity, autoimmunity, and tumor Immunity. Thus, targeting TIM-3 emerges as a promising approach for further improvement of current immunotherapy. Despite a large amount of experimental data showing an immune suppressive function of TIM-3 in vivo, the exact mechanisms are not well understood. To enable effective targeting of TIM-3 for tumor immunotherapy, further in-depth mechanistic studies are warranted. These studies will also provide much-needed insight for the rational design of novel combination therapy with other checkpoint blockers. In this review, we summarize key evidence supporting an immune regulatory role of TIM-3 and discuss possible mechanisms of action.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
|
| Date: |
16 March 2017 |
| Date Type: |
Publication |
| Journal or Publication Title: |
International Journal of Molecular Sciences |
| Volume: |
18 |
| Number: |
3 |
| Publisher: |
MDPI AG |
| DOI or Unique Handle: |
10.3390/ijms18030645 |
| Schools and Programs: |
School of Medicine > Immunology |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
TIM-3, T cell subsets, tumor microenvironment, antitumor immune responses |
| ISSN: |
1422-0067 |
| Official URL: |
http://dx.doi.org/10.3390/ijms18030645 |
| Funders: |
Head and Neck Cancer Spore Development award, Roswell Park Cancer Institute/University of Pittsburgh Cancer Institute Ovarian Cancer Specialized Programs of Research Excellence, National Natural Science Foundation of China |
| Article Type: |
Research Article |
| Date Deposited: |
04 Feb 2021 18:13 |
| Last Modified: |
04 Feb 2021 18:13 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/40213 |
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