Multimodal Investigation of the Efficiency and Stability of Microstimulation using Electrodes Coated with PEDOT/CNT and Iridium Oxide

Zheng, Xin Sally (2021) Multimodal Investigation of the Efficiency and Stability of Microstimulation using Electrodes Coated with PEDOT/CNT and Iridium Oxide. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

Electrical microstimulation is an invaluable tool in neuroscience research to dissect neural circuits, relate brain areas, and identify relationships between brain structure and behavior. In the clinic, electrical microstimulation has enabled partial restoration of vision, movement, sensation and autonomic functions. Recently, novel materials and new fabrication techniques of traditional metals have emerged such as iridium oxide and the conducting polymer PEDOT/CNT. These materials have demonstrated particular promise in the improvement in electrical efficiency. However, the in vivo stimulation efficiency and the in vivo stability of these materials have not been thoroughly characterized. In this dissertation, we use a multimodal approach to study the efficiency and stability of electrode-tissue interface using novel materials in microstimulation.

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Details

Item Type:	University of Pittsburgh ETD
Status:	Unpublished
Creators/Authors:	Creators Email Pitt Username ORCID Zheng, Xin Sally xiz149@pitt.edu xiz149
ETD Committee:	Title Member Email Address Pitt Username ORCID Committee Chair Cui, Xinyan xic11@pitt.edu xic11 Committee Member Kozai, Takashi tdk18@pitt.edu tdk18 Committee Member Fisher, Lee lef44@pitt.edu lef44 Committee Member Turner, Robert rturner@pitt.edu rturner Committee Member Vazquez, Alberto alv15@pitt.edu alv15
Date:	13 June 2021
Date Type:	Publication
Defense Date:	26 January 2021
Approval Date:	13 June 2021
Submission Date:	18 February 2021
Access Restriction:	No restriction; Release the ETD for access worldwide immediately.
Number of Pages:	201
Institution:	University of Pittsburgh
Schools and Programs:	Swanson School of Engineering > Bioengineering
Degree:	PhD - Doctor of Philosophy
Thesis Type:	Doctoral Dissertation
Refereed:	Yes
Uncontrolled Keywords:	microstimulation, conducting polymers, iridium oxide, in vivo imaging
Date Deposited:	13 Jun 2021 17:25
Last Modified:	13 Jun 2021 17:25
URI:	http://d-scholarship.pitt.edu/id/eprint/40272

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