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Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients

Hussein, Mohsen and van Eck, Carola F. and Kregar Velikonja, Nevenka (2021) Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients. Applied Sciences, 11 (7). p. 2932. ISSN 2076-3417

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Abstract

The aim of this study was to evaluate and compare the effectiveness of three different intra-articular injective treatments: hyaluronic acid (HA), autologous conditioned serum (ACS) and bone marrow aspirate concentrate (BMAC) for the treatment of knee osteoarthritis (OA). A Level III retrospective comparative clinical study was performed on 505 consecutive patients treated with HA (<i>n</i> = 171), ACS (<i>n</i> = 222) or BMAC (<i>n</i> = 112) for knee OA. The mean patient age was 52 ± 13 years; 54.5% were males. Collected data included patient demographics, symptoms, visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and radiographic classification of osteoarthritis grade using plain radiographs and advanced imaging. Clinical outcome was assessed at 3 and 12 months post treatment. Significant improvement in VAS and WOMAC was seen for all three treatments at the 3-month follow-up. At 12 months, VAS was improved in all three treatment groups, yet only BMAC sustained the improved WOMAC even in patients with more severe degenerative changes. This study shows that BMAC is more effective than HA and ACS in the treatment of symptomatic knee OA, especially in the patients with more severe degenerative changes.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hussein, Mohsen
van Eck, Carola F.cfv3@pitt.educfv3
Kregar Velikonja, Nevenka
Date: 25 March 2021
Date Type: Publication
Journal or Publication Title: Applied Sciences
Volume: 11
Number: 7
Publisher: MDPI AG
Page Range: p. 2932
DOI or Unique Handle: 10.3390/app11072932
Schools and Programs: School of Medicine > Orthopaedic Surgery
Refereed: Yes
Uncontrolled Keywords: osteoarthritis, knee, hyaluronic acid, autologous conditioned serum, bone marrow aspirate concentrate, clinical outcome
ISSN: 2076-3417
Official URL: http://dx.doi.org/10.3390/app11072932
Funders: Public Scholarship, Development, Disability and Maintenance Fund of the Republic of Slovenia
Article Type: Research Article
Date Deposited: 25 May 2021 19:38
Last Modified: 25 May 2021 19:38
URI: http://d-scholarship.pitt.edu/id/eprint/41143

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