Hartnett, Erin G. and Knight, Julia and Radolec, Mackenzy and Buckanovich, Ronald J. and Edwards, Robert P. and Vlad, Anda M.
(2020)
Immunotherapy Advances for Epithelial Ovarian Cancer.
Cancers, 12 (12).
p. 3733.
ISSN 2072-6694
Abstract
New treatment modalities are needed in order to improve the prognosis of women diagnosed with epithelial ovarian cancer (EOC), the most aggressive gynecologic cancer type. Most ovarian tumors are infiltrated by immune effector cells, providing the rationale for targeted approaches that boost the existing or trigger new anti-tumor immune mechanisms. The field of immuno-oncology has experienced remarkable progress in recent years, although the results seen with single agent immunotherapies in several categories of solid tumors have yet to extend to ovarian cancer. The challenge remains to determine what treatment combinations are most suitable for this disease and which patients are likely to benefit and to identify how immunotherapy should be incorporated into EOC standard of care. We review here some of the most promising immune therapies for EOC and focus on those currently tested in clinical trials.
Share
| Citation/Export: |
|
| Social Networking: |
|
Details
| Item Type: |
Article
|
| Status: |
Published |
| Creators/Authors: |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Magee-Women's Research Institute |
| Date: |
11 December 2020 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Cancers |
| Volume: |
12 |
| Number: |
12 |
| Publisher: |
MDPI AG |
| Page Range: |
p. 3733 |
| DOI or Unique Handle: |
10.3390/cancers12123733 |
| Schools and Programs: |
School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
epithelial ovarian cancer, immune therapy, cancer vaccines, immune checkpoint inhibitors, CAR T cells, oncolytic viruses |
| ISSN: |
2072-6694 |
| Official URL: |
http://dx.doi.org/10.3390/cancers12123733 |
| Funders: |
Department of Defense Ovarian Cancer Research Program, National Institute of Health, Team Science Award from the Ovarian Cancer Research Fund Alliance |
| Article Type: |
Review |
| Date Deposited: |
04 Jun 2021 17:24 |
| Last Modified: |
04 Jun 2021 17:24 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/41254 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Altmetric.com
Actions (login required)
 |
View Item |
![[feed]](/images/feed-icon-32x32.png){kind=icon}