Yazdani, Hamza and Huang, Hai and Tsung, Allan
(2019)
Autophagy: Dual Response in the Development of Hepatocellular Carcinoma.
Cells, 8 (2).
p. 91.
ISSN 2073-4409
(Submitted)
Abstract
Autophagy is an evolutionary conserved intracellular mechanism which helps eukaryotic cells in maintaining their metabolic state to afford high-efficiency energy requirements. In the physiology of a normal liver and the pathogenesis of liver diseases, autophagy plays a crucial role. Autophagy has been found to be both upregulated and downregulated in different cancers providing the evidence that autophagy plays a dual role in suppressing and promoting cell survival. Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the major leading cause of cancer mortality worldwide. In light of its high complexity and poor prognosis, it is essential to improve our understanding of autophagy’s role in HCC. In this review, we summarize the dual mechanism of autophagy in the development of HCC and elucidate the currently used therapeutic strategies for anti-HCC therapy
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Details
| Item Type: |
Article
|
| Status: |
Submitted |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Yazdani, Hamza | hoy20@pitt.edu | hoy20 | | | Huang, Hai | | | | | Tsung, Allan | | | |
|
| Date: |
28 January 2019 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Cells |
| Volume: |
8 |
| Number: |
2 |
| Publisher: |
MDPI AG |
| Page Range: |
p. 91 |
| DOI or Unique Handle: |
10.3390/cells8020091 |
| Schools and Programs: |
School of Medicine > Surgery |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
hepatocellular carcinoma, inflammation, mitophagy, oxidative stress, HCC therapy |
| ISSN: |
2073-4409 |
| Official URL: |
http://dx.doi.org/10.3390/cells8020091 |
| Funders: |
National Institute of Health |
| Article Type: |
Review |
| Date Deposited: |
29 Jun 2021 18:47 |
| Last Modified: |
29 Jun 2021 18:47 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/41305 |
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