Lee, P and Murase, N and Todo, S and Makowka, L and Starzl, T
(1987)
The immunosuppressive effects of FR 900506 in rats receiving heterotopic cardiac allografts.
Surgical Research Communications, 1 (4).
325 - 331.
ISSN 0882-9233
Abstract
The immunosuppressive effects of FR 900506 were studied in Lewis rats given ACI heterotopic heart allografts. Intramuscular doses of 0.02 mg/kg daily for 2 weeks extended graft survival slightly, and with doses up to 1.28 mg/kg for 2 weeks, there is long-term survival. If only 3 daily doses were given starting on day 4 after transplantation, graft survival for almost 3 months was accomplished in 4 of 6 animals who still bear functioning hearts.
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