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Evidence for hyperacute rejection of human liver grafts: The case of the canary kidneys

Starzl, TE and Demetris, AJ and Todo, S and Kang, Y and Tzakis, A and Duquesnoy, R and Makowka, L and Banner, B and Concepcion, W and Porter, KA (1989) Evidence for hyperacute rejection of human liver grafts: The case of the canary kidneys. Clinical Transplantation, 3 (1). 37 - 45. ISSN 0902-0063

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Abstract

Sequential liver and kidney transplantation from the same donor was performed in 2 patients. The kidney in Patient 1, which was transplanted after the liver, was hyperacutely rejected and removed 6 hours later. The first liver as well as another liver transplanted 3 days later developed widespread hemorrhagic necrosis. Although the cytotoxic crossmatch of preoperative recipient serum with both donors was negative, patchy widespread IgM and C(1q) deposits were found in all 3 organs. In Patient 2, who had a strongly positive cytotoxic crossmatch with his donor, the liver suffered a massive but reversible injury, while the kidney never functioned. Both patients developed a coagulopathy a few minutes after liver revascularization. The kidneys in these cases had served like the canaries which miners once used to detect a hostile environment and their presence made more understandable how an indolent version of hyperacute rejection of the liver can take place.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Demetris, AJ
Todo, S
Kang, Y
Tzakis, A
Duquesnoy, R
Makowka, L
Banner, B
Concepcion, W
Porter, KA
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Clinical Transplantation
Volume: 3
Number: 1
Page Range: 37 - 45
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0902-0063
Other ID: uls-drl:31735062130848, Starzl CV No. 934
Date Deposited: 08 Apr 2010 17:15
Last Modified: 27 Jan 2019 02:55
URI: http://d-scholarship.pitt.edu/id/eprint/4320

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