Glenn, R and Linda, FH and Frank, WC and David, JB and Sandee, S and Roxann, C and Robert, LH and Bartley, PG and Thomas, ES
(1989)
Low rate of rhesus immunization from rh- incompatible blood transfusions during liver and heart transplant surgery.
Transplantation, 47 (6).
993 - 995.
ISSN 0041-1337
Abstract
Transfusion of one unit or more of Rh-positive red blood cells normally causes circulating anti-D antibody to appear 2-6 months later in 80-95% of Rh persons. We asked whether transplant immunosuppression with cyclosporine and corticosteroids affects Rh immuniza¬tion. Nineteen Rh" liver, heart, and heart-lung transplant recipients received 3—153 (median: 10) units of Rh+ RBCs at surgery and were tested for anti-D >2 months later. Three patients developed anti-D at 11—15 days; one may have had an unusually rapid primary immune response and two were secondary to previous exposure by pregnancy. None of the other 16 patients had anti-D when tested 2.5-51 months later (13 patients, >11.5 months). This low rate of Rhesus immunization in association with cyclosporine immunosuppression allows greater flexibility in meeting the transfusion needs of Rh- liver and heart transplant patients. Caution is still advised in young females and in patients who may have been previously exposed to Rh+ RBCs by transfusion or by pregnancy prior to the availability of perinatal Rh immune globulin twenty years ago. Other humoral immune responses to some vaccines or infectious agents may also be impaired in transplant patients© 1989 by The Williams and Wilkins Co.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Glenn, R | | | | | Linda, FH | | | | | Frank, WC | | | | | David, JB | | | | | Sandee, S | | | | | Roxann, C | | | | | Robert, LH | | | | | Bartley, PG | | | | | Thomas, ES | | | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1989 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Transplantation |
| Volume: |
47 |
| Number: |
6 |
| Page Range: |
993 - 995 |
| DOI or Unique Handle: |
10.1097/00007890-198906000-00015 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0041-1337 |
| Other ID: |
uls-drl:31735062130962, Starzl CV No. 947 |
| Date Deposited: |
08 Apr 2010 17:16 |
| Last Modified: |
19 Jun 2020 14:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/4333 |
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