Samuelsson, Laura B.
(2022)
SELF-REPORTED SLEEP DURATION, SLEEP TIMING, SLEEP DISTURBANCE, AND SLEEP HEALTH AND ASSOCIATIONS WITH INCIDENT BREAST CANCER RISK IN A PROSPECTIVE, LONGITUDINAL COHORT OF WOMEN DURING THE MENOPAUSAL TRANSITION:
THE STUDY OF WOMEN’S HEALTH ACROSS THE NATION.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
This is the latest version of this item.
Abstract
Restorative sleep and optimal sleep-wake schedules are becoming luxuries in contemporary industrialized cultures. Paradoxically, there is an increasing awareness of the adverse effects of sleep and circadian disruptions on health, although studies have often overlooked the interrelatedness of these systems and potential combined effects. Research on circadian rhythms, sleep, and oncogenesis has been rapidly growing in recent years. Breast cancer has been a particular focus of attention. Since breast cancer risk is positively associated both with age and estrogen exposure, the menopausal transition may represent a critical period in which to examine exposure to sleep and circadian disruption in women in order to better understand how these putative risk factors may associate with incident breast cancer risk.
In the present study, a broadened model of circadian disruption of mammary oncogenesis was proposed to (a) consider the effects of a sleep health index including sleep duration, timing, and disturbance; (b) account for the interrelated nature of the circadian and sleep systems; and (c) apply to the female population at large. Evidence-based review was presented of this expanded model of sleep and circadian disruption of mammary oncogenesis, including a critical review of the state-of-science of the associations between circadian disruption, sleep, and breast cancer (Samuelsson et al., 2018). Three of the consistent limitations among the extant research studies are the use of single measures of risk factors assessed at a single timepoint, retrospective or cross-sectional designs, and including menopausal status only as a model covariate. These limitations precluded our identifying patterns of trajectories for risk factors across the menopausal transition, as well as any causal interpretations of associations with incident breast cancer. Two programmatic studies were conducted in a longitudinal, multi-ethnic cohort of community women to (1) characterize overall exposure to a comprised of sleep duration, timing, and disturbance as well as two sleep health indices, one for short sleepers and one for long sleepers, within the framework of the menopausal transition; and (2) examine whether the individual sleep and circadian risk factors and overall poor sleep health exposure was associated with incident breast cancer risk in menopausal women.
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Details
| Item Type: |
University of Pittsburgh ETD
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| Status: |
Unpublished |
| Creators/Authors: |
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| ETD Committee: |
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| Date: |
13 August 2022 |
| Date Type: |
Publication |
| Defense Date: |
6 June 2022 |
| Approval Date: |
4 December 2024 |
| Submission Date: |
5 August 2022 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
104 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Psychology |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
breast cancer
cancer
sleep
circadian rhythms
sleep timing
sleep duration
sleep disturbance
light at night
menopause
menopausal transition
women's health |
| Date Deposited: |
04 Dec 2024 16:57 |
| Last Modified: |
04 Dec 2024 18:08 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/43688 |
Available Versions of this Item
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SELF-REPORTED SLEEP DURATION, SLEEP TIMING, SLEEP DISTURBANCE, AND SLEEP HEALTH AND ASSOCIATIONS WITH INCIDENT BREAST CANCER RISK IN A PROSPECTIVE, LONGITUDINAL COHORT OF WOMEN DURING THE MENOPAUSAL TRANSITION:
THE STUDY OF WOMEN’S HEALTH ACROSS THE NATION. (deposited 04 Dec 2024 16:57)
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