Akkur, Avinash and Vieira, Alexandre R and Bezamat, Mariana and Verdelis, Konstantinos
(2023)
Factors Modulating Responses of Oral Hygiene Instructions.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Background: High Blood Pressure (HBP) and Periodontal disease (PD) are prevalent chronic disorders. HBP is known to impact cardiovascular disease (CVD) complications significantly, and PD has also been vastly studied regarding its potential involvement with CVD. The present study analyses the association of risk factors like hypertension and pro-inflammatory cytokines like IL- 1a and IL-1b in the subjects who have received non-surgical therapy and oral hygiene instructions for periodontitis.
Methods: Clinical data and genomic DNA samples (saliva) were obtained from the University of Pittsburgh Dental Registry and DNA Repository (DRDR) project. A total of 578 subjects from both sexes were considered by checking their periodontal and hypertension status using an electronic health record system. All the participants were divided into four groups. Group A: consists of healthy subjects without PD and HBP; Group B: subjects with PD and HBP; Group C: subjects with PD but without HBP; Group D: subjects without PD but having HBP. They were examined on more than one visit to assess their periodontal status after non-surgical intervention and oral hygiene instructions. The patients were classified as Improved, Worsened, and Neutral based on their plaque score before and after the intervention. We genotyped all the samples using SNPs rs1800587 (IL-1a) and rs1143634 (IL-1b). We studied the association ofIL-1with periodontitis and hypertension by comparing groups B, C, and D with group A, and its sex predilection was also analysed. In addition, we studied the role of IL-1a and IL-1b in affecting the oral hygiene status of the subjects by comparing their plaque indices from the first and second visits.
Results: IL-1a was associated with subjects having only PD (p<0.05), and IL-1b was associated with subjects having both PD and HBP (p<0.05). The oral hygiene status showed a significant improvement after non-surgical therapy and oral hygiene instructions in subjects with both PD and HBP and was associated with the IL-1b (p<0.05). However, there was no sex predilection (p >0.05).
Conclusion:Our data showed that despite the multifactorial nature of PD, a significant improvement could be noticed in subjects undergoing non-surgical intervention and strictly following oral hygiene instructions.
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Details
| Item Type: |
University of Pittsburgh ETD
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| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
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| Date: |
23 May 2023 |
| Date Type: |
Publication |
| Defense Date: |
6 April 2023 |
| Approval Date: |
23 May 2023 |
| Submission Date: |
28 April 2023 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
85 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Dental Medicine > Dental Science |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
PD-Periodontal disease, HBP- High blood pressure |
| Date Deposited: |
23 May 2023 12:31 |
| Last Modified: |
23 May 2023 12:31 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/44801 |
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