The Association of VMAT2 Gene Polymorphisms With the Development of SchizophreniaCenname, Alexis (2023) The Association of VMAT2 Gene Polymorphisms With the Development of Schizophrenia. Master's Thesis, University of Pittsburgh. (Unpublished)
AbstractObjective: To investigate the association between common single nucleotide polymorphisms (SNPs) in the vesicular monoamine transporter type 2 (VMAT2 ) gene and a diagnosis Methods: 968 individuals with a diagnosis of schizophrenia were ancestry-matched to healthy controls to create a final cohort of 1,936 individuals. Diagnosis criteria was determined from Electronic Health Records provided by the AllofUs Research Program. Additive and dominant logistic regression analyses were done for the promoter SNPs rs363324 Results: No significant results were observed for rs363324 and rs363371 using the additive model. The dominant model suggested a protective effect for rs363324 for the entire Conclusion: Premature mortality rates and the need for targeted treatments in schizophrenia make it an important disease to study for public health. This study found that ’GA’ and ’AA’ genotypes have an equal protective effect from the development of schizophrenia for rs363324. Unlike previous studies, the results for rs363371 were not significant. Future studies should use a larger sample size and include variables concerning environmental factors. Share
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