Keely, FitzGerald
(2023)
Identifying Clusters of Orthologous Genes Undergoing Forward Selection in Staphylococcus aureus Using Omega Metrics.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
In collaboration with the Wright lab and other members of the Richardson lab, I have identified core Staphylococcus aureus clusters of orthologous genes (COGs) undergoing forward selection. Unlike purifying selection, which demands sequence conservation to prevent fitness loss, COGs undergoing forward selection change more rapidly than expected at the protein level. These COGs may, therefore, confer an adaptive advantage to the evolving organism. Using genomegaMap, a tool created by Dr. Daniel Wilson, I have examined evolutionary rates both between and within COGs by estimating the ratios of nonsynonymous to synonymous mutation, also known as omega or dN/dS ratios. In so doing, I have identified COGs that may be important to understanding the increasing pathogenicity of S. aureus. Specifically, these COGs appear to be evidence of forward selection in metabolic pathways associated with phosphate, nitrogen, and ATP-generating metabolism.
Share
| Citation/Export: |
|
| Social Networking: |
|
Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
14 December 2023 |
| Defense Date: |
12 December 2023 |
| Approval Date: |
16 September 2024 |
| Submission Date: |
14 December 2023 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
40 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Medicine > Medicine |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Clusters of Orthologous Genes, Forward Selection, Omega |
| Related URLs: |
|
| Date Deposited: |
16 Sep 2024 18:55 |
| Last Modified: |
16 Sep 2024 18:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/45680 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
 |
View Item |
![[img]](https://d-scholarship.pitt.edu/45680/2/image5.png)
![[img]](https://d-scholarship.pitt.edu/45680/3/image10.png)
![[img]](https://d-scholarship.pitt.edu/45680/4/image11.png)
![[img]](https://d-scholarship.pitt.edu/45680/5/image3.png)
![[img]](https://d-scholarship.pitt.edu/45680/6/image2.png)
![[img]](https://d-scholarship.pitt.edu/45680/7/image9.png)
![[img]](https://d-scholarship.pitt.edu/45680/8/image4.png)
![[img]](https://d-scholarship.pitt.edu/45680/9/image6.png)
![[img]](https://d-scholarship.pitt.edu/45680/10/image8.png)
![[img]](https://d-scholarship.pitt.edu/45680/11/image1.png)
![[img]](https://d-scholarship.pitt.edu/45680/12/image7.png)
![[img]](https://d-scholarship.pitt.edu/style/images/fileicons/application_vnd.ms-excel.png)
![[feed]](/images/feed-icon-32x32.png){kind=icon}
