Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form
D-Scholarship @ Pitt Banner and Links to Homepage

The question of FK 506 nephrotoxicity after liver transplantation.

McCauley, J and Takaya, S and Fung, J and Tzakis, A and Abu-Elmagd, K and Jain, A and Todo, S and Starzl, TE (1991) The question of FK 506 nephrotoxicity after liver transplantation. Transplant Proc, 23 (1 Pt 2). 1444 - 1447. ISSN 0041-1345

[img]
Preview
 PDF
Accepted Version
Available under License : See the attached license file.
Download (659kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.
Download (1kB)

Abstract

Formal studies have not been published on the nephrotoxicity of FK 506 when the drug was used from the outset. This kind of information was sought in 101 recipients of primary livers, 24 hearts, and 3 double lungs or heart-lung. Perioperative renal dysfunction was commonly seen, which appeared to be related to FK 506 doses and plasma levels, particularly when the drug was given IV. This was reversible. Late renal function has been generally satisfactory in all three cohorts of patients, and the incidence of hypertension has been low. The therapeutic index of FK 506 is a good one, as revealed by these observations in patients whose most notable achievement was a low mortality.

Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
McCauley, J
Takaya, S
Fung, J
Tzakis, A
Abu-Elmagd, K
Jain, A
Todo, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: February 1991
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 23
Number: 1 Pt 2
Page Range: 1444 - 1447
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Anti-Bacterial Agents, Creatinine, Dose-Response Relationship, Drug, Heart Transplantation, Heart-Lung Transplantation, Humans, Immunosuppression Therapy, Immunosuppressive Agents, Kidney Diseases, Liver Transplantation, Lung Transplantation, Tacrolimus
ISSN: 0041-1345
Funders: NIDDK NIH HHS (R01 DK029961-19), PHS HHS (29961)
Other ID: uls-drl:31735062117365, Starzl CV No. 1184
Date Deposited: 08 Apr 2010 17:20
Last Modified: 18 Dec 2021 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/4570

Metrics

Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item