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Radiation therapy for primary carcinoma of the extrahepatic biliary system. An analysis of 63 cases.

Flickinger, JC and Epstein, AH and Iwatsuki, S and Carr, BI and Starzl, TE (1991) Radiation therapy for primary carcinoma of the extrahepatic biliary system. An analysis of 63 cases. Cancer, 68 (2). 289 - 294. ISSN 0008-543X

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Abstract

From 1976 to 1988, 63 patients received radiation therapy for primary cancers of the extrahepatic biliary system (eight gallbladder and 55 extrahepatic biliary duct). Twelve patients underwent orthotopic liver transplantation. Chemotherapy was administered to 13 patients. Three patients underwent intraluminal brachytherapy alone (range, 28 to 55 Gy). Sixty patients received megavoltage external-beam radiation therapy (range, 5.4 to 61.6 Gy; median, 45 Gy), of whom nine received additional intraluminal brachytherapy (range, 14 to 45 Gy; median, 30 Gy). The median survival of all patients was 7 months. Sixty patients died, all within 39 months of radiation therapy. One patient is alive 11 months after irradiation without surgical resection, and two are alive 50 months after liver transplantation and irradiation. Symptomatic duodenal ulcers developed after radiation therapy in seven patients but were not significantly related to any clinical variable tested. Extrahepatic biliary duct cancers, the absence of metastases, increasing calendar year of treatment, and liver transplantation with postoperative radiation therapy were factors significantly associated with improved survival.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Flickinger, JC
Epstein, AH
Iwatsuki, S
Carr, BI
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 15 July 1991
Date Type: Publication
Journal or Publication Title: Cancer
Volume: 68
Number: 2
Page Range: 289 - 294
DOI or Unique Handle: 10.1002/1097-0142(19910715)68:2<289::aid-cncr2820680213>3.0.co;2-2
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Bile Duct Neoplasms, Brachytherapy, Carcinoma, Combined Modality Therapy, Duodenal Ulcer, Female, Gallbladder Neoplasms, Humans, Liver Transplantation, Male, Middle Aged, Radiation Injuries, Radiotherapy Dosage, Survival Rate
ISSN: 0008-543X
Funders: NIDDK NIH HHS (R01 DK029961-19)
Other ID: uls-drl:31735062117514, Starzl CV No. 1199
Date Deposited: 08 Apr 2010 17:20
Last Modified: 02 Jul 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/4585

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