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Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506

Francavilla, A and Starzl, TE and Barone, M and Zeng, Q‐ and Porter, KA and Zeevi, A and Markus, PM and van den Brink, MRM and Todo, S (1991) Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506. Hepatology, 14 (1). 140 - 143. ISSN 0270-9139

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Abstract

Evidence could not be found of immune modulation of liver regeneration. The powerful immunosuppressive drug FK 506, which augments the response after partial hepatectomy in normal rats, had the same effect in T cell—deficient nude rats. The cytotoxicity of natural killer cells in treated nude rats was not significantly changed by FK 506 therapy. However, the serum of FK 506—treated nude rats increased hepatocyte proliferation when added to third‐party hepatocyte cultures, suggesting that FK 506 had induced a serum growth factor in the nude rats or had suppressed an inhibitory factor. A hypothesis was advanced that FK 506 (and cyclosporine) affects hepatic growth by nonimmunological pathways. (HEPATOLOGY 1991;14:140–143.) Copyright © 1991 American Association for the Study of Liver Diseases

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Francavilla, A
Starzl, TEtes11@pitt.eduTES11
Barone, M
Zeng, Q‐
Porter, KA
Zeevi, A
Markus, PM
van den Brink, MRM
Todo, S
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 14
Number: 1
Page Range: 140 - 143
DOI or Unique Handle: 10.1002/hep.1840140123
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062117605, Starzl CV No. 1209
Date Deposited: 08 Apr 2010 17:20
Last Modified: 03 Aug 2020 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/4595

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