Ricordi, C and Zeng, Y and Alejandro, R and Tzakis, A and Venkataramanan, R and Fung, J and Bereiter, D and Mintz, DH and Starzl, TE
(1991)
In vivo effect of FK506 on human pancreatic islets.
Transplantation, 52 (3).
519 - 522.
ISSN 0041-1337
Abstract
The purpose of this study was to evaluate the in vivo effect of FK506 on human pancreatic islets. Twenty-five nude mice were made diabetic by one intravenous injection of streptozotocin. Approximately 600 islets were administered in the renal subcapsular space 3-5 days following streptozotocin administration. One week after transplantation, the mice were divided in four groups. In group 1, the animals received 1 injection of 0.5 ml of diluent i.p. daily for one week. In groups 2, 3, and 4 the treatments were daily i.p. injection of 0.3, 1, and 3 mg/kg FK506, respectively. After treatment, the functional integrity of the transplanted human islets was tested by measuring the plasma glucose and human C-peptide response to intraperitoneal glucose injection in groups 1 and 4. IPGTT alone was assessed in groups 2 and 3. The results indicate that i.p. administration of FK506 for one week at a dose 0.3 mg/kg/day did not result in any significant alteration of glucose disappearance and C-peptide response to IPGTT. Higher doses of FK506 produced a significant delay in glucose disappearance in groups 3 and 4, and a significant inhibition of glucose-mediated C-peptide response in group 4. © 1991 by Williams and Wilkins.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Ricordi, C | | | | | Zeng, Y | | | | | Alejandro, R | | | | | Tzakis, A | | | | | Venkataramanan, R | rv@pitt.edu | RV | | | Fung, J | | | | | Bereiter, D | | | | | Mintz, DH | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1991 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Transplantation |
| Volume: |
52 |
| Number: |
3 |
| Page Range: |
519 - 522 |
| DOI or Unique Handle: |
10.1097/00007890-199109000-00026 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0041-1337 |
| Other ID: |
uls-drl:31735062117613, Starzl CV No. 1210 |
| Date Deposited: |
08 Apr 2010 17:20 |
| Last Modified: |
02 Aug 2020 10:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/4596 |
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