Bangquan, Liao
(2024)
Mechanical and Structural Anisotropy Analysis of Equatorial Sclera.
Master's Thesis, University of Pittsburgh.
(Unpublished)
This is the latest version of this item.
Abstract
Sclera, the outer structure of an eye, plays a vital role in ocular biomechanics, protecting the inner ocular structures from mechanical deformation and serving as the main load-bearing connective tissue. The sclera consists of 95% type I collagen fibers with type III, V, VI comprising most of the remaining 5%. Thus, studying this structure is valuable for understanding biomechanically related diseases. Our study focuses on the sclera’s mechanical and structural anisotropies. We performed a systematic quantitative study using equal biaxial tensile test and fiber orientation analysis (through Polarized light Microscopy) to measure the mechanical and structural anisotropies of 4 quadrants of the sclera: nasal, superior, temporal, and inferior. We found the following: First, the equatorial sclera was stiffer in the equatorial direction than in the meridional direction. Second, the majority of our sample’s fibers were preferentially aligned in meridional direction. Third, the mechanical anisotropy of the equatorial sclera did not always concur with its structural anisotropy. Our results challenge the conventional assumption that fiber alignment in structural anisotropy is consistent with mechanical anisotropy. This could be an entry point to have a better understanding of biomechanical property of this structure.
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Details
| Item Type: |
University of Pittsburgh ETD
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| Status: |
Unpublished |
| Creators/Authors: |
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| ETD Committee: |
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| Date: |
3 June 2024 |
| Date Type: |
Publication |
| Defense Date: |
21 March 2024 |
| Approval Date: |
3 June 2024 |
| Submission Date: |
26 March 2024 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
52 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Swanson School of Engineering > Bioengineering |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Anisotropy; Equatorial Sclera |
| Date Deposited: |
03 Jun 2024 14:42 |
| Last Modified: |
03 Jun 2024 14:42 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/46089 |
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Mechanical and Structural Anisotropy Analysis of Equatorial Sclera. (deposited 03 Jun 2024 14:42)
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