Randhawa, PS and Jaffe, R and Demetris, AJ and Nalesnik, M and Starzl, TE and Chen, YY and Weiss, LM
(1991)
The systemic distribution of Epstein-Barr virus genomes in fatal post-transplantation lymphoproliferative disorders: An in situ hybridization study.
American Journal of Pathology, 138 (4).
1027 - 1033.
ISSN 0002-9440
Abstract
The systemic distribution of Epstein-Barr virus (EBV) genomes was studied in paraffin-embedded tissues from 12 fatal cases of Post-transplantation lymphoproliferative disease (PTLD), using an in situ hybridization technique employing an alpha-35S-dCTP-radiolabeled BamHI-W fragment of EBV DNA. The presence of EBV was documented in various PTLD-involved organs. The hybridization signal for the virus localized predominantly in the abnormal lymphoid cells, but signals also were detected in hepatocytes and/or adrenal cortical cells in five cases. The distribution of autoradiographic label within the lymphoid cells was focal and its intensity varied from field to field, suggesting a nonuniformity of the viral genomic load in the infected tissues. Recruitment of EBV genome-bearing cells was not observed into inflammatory mononuclear infiltrates found in organs without histopathologic evidence of PTLD.
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