Brown, Lois E.
(1989)
The Effect of pH Changes on the Levels of Alpha-Galactosidase A in a Patient with Fabry's Disease, Post Renal Transplant.
Master's Thesis, University of Pittsburgh.
Abstract
Fabry's disease (alpha-galactosidase A deficiency) leads to early renal failure. Unfortunately, kidney transplants do not always reliably supply the deficient enzyme. To assess urinary and serum activity of alpha-galactosidase A by the transplant as well as the relationship between urinary and serum hydrolase activity, acid-base studies were performed in normal controls and in a patient with Fabry' s disease post renal transplant. Alkalinization was induced by intravenous sodium bicarbonate and acidification by acetazolamide administration. The results show that alpha-galactosidase A is secreted by the renal graft, but that administration of sodium bicarbonate and acetazolamide variably alter the excretion and reabsorption of alpha-galactosidase, as well as other lysosomal hydrolases, specifically beta-hexosaminidase and beta-glucuronidase. Therefore, these methods do not appear useful for treating Fabry' s disease post renal transplant. The large changes in hydrolase excretion induced by the pH changes also demonstrate the difficulty of using lysosomal enzymuria as a diagnostic marker for renal disorders without knowledge of acid-base conditions.
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Details
| Item Type: |
Other Thesis, Dissertation, or Long Paper
(Master's Thesis)
|
| Status: |
Unpublished |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Brown, Lois E. | | | |
|
| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID |
|---|
| Committee Chair | Glew, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Committee Member | Chen, Alice | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Committee Member | Klinosky, Bernard | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
|
| Date: |
1989 |
| Date Type: |
Completion |
| Number of Pages: |
65 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Health and Rehabilitation Sciences > Health and Rehabilitation Sciences |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Date Deposited: |
24 Jul 2024 13:53 |
| Last Modified: |
24 Jul 2024 13:53 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/46738 |
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