Wise, Noah N K
(2024)
FRAX® Score Distribution and Associated Risk Factors in Older Women and Men: The Study of Muscle, Mobility and Aging – Bone Ancillary.
Master Essay, University of Pittsburgh.
Abstract
FRAX® is a risk-assessment tool physicians use to estimate the risk of a major osteoporotic (MOF) or hip (HF) fracture in the next ten years of life. This study aimed to determine factors associated with higher FRAX® scores in older men and women enrolled in the Study of Muscle, Mobility and Aging (SOMMA) Bone Study.
The SOMMA study participants were >70 years, able to complete a 400-meter walk at baseline, and free of advanced chronic disease. The SOMMA Bone Study at the Pittsburgh site was after the 12-month SOMMA visit to measure femoral neck areal bone mineral density (aBMD) using Dual-energy X-Ray Absorptiometry (DXA), and bone structure/microarchitecture using High-Resolution peripheral Quantitative Computed Tomography (N=329 ; 76.2+4.6 years; 60.6% female, 87.2% White; N=319 with available BMD). The FRAX® variables used were age (years); sex (M/F); height (cm); weight (kg); Y/N history of self and parent fracture, glucocorticoid use, smoking, and rheumatoid arthritis; secondary osteoporosis (all no); drinking (>3 units/day: all no); BMD (g/cm2). Scores were also calculated without BMD. Univariate descriptive statistics were calculated for FRAX® scores by sex and age categories with χ2 and Wilcoxon Rank-Sum tests (SAS).
FRAX® score medians (range) for MOF and HF with BMD were 11.0% (2.9-70) and 2.8% (0.1-64), respectively, and higher overall median without BMD: 15.0% (3.8-64) and 5.2% (0.8-52), respectively. Women had significantly higher scores with BMD than men; 15.0% vs. 6.8% for MOF and 3.8% vs. 2.0% for HF (p<0.0001). Similarly, those >80 years had significantly higher scores vs. <80 years: 13.5% vs. 11.0% for MOF, and 4.7% vs. 2.6% for HF (both p<0.01), respectively. Obese BMI was associated with significantly lower median scores vs. overweight or normal BMI for all outcomes except MOF with BMD (all p<0.001). Those with arthritis had higher FRAX® scores for all outcomes except HF with BMD. Non-White participants had significantly lower scores only in HF with BMD vs. White participants (p<0.01). Other factors were not associated with FRAX® scores. Many risk factors for higher FRAX® scores were found in the population of older adults and should be addressed in public health efforts to prevent fractures.
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Details
| Item Type: |
Other Thesis, Dissertation, or Long Paper
(Master Essay)
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID  |
|---|
| Committee Chair | Strotmeyer, Elsa S. | strotmeyere@edc.pitt.edu | strotmeyere | UNSPECIFIED | | Committee Member | Koltun, Kristen J. | kjk116@pitt.edu | kjk116 | UNSPECIFIED | | Committee Member | Freeland, Kerri S. | ksf28@pitt.edu | ksf28 | UNSPECIFIED | | Committee Member | Glynn, Nancy W. | EPIDNWG@pitt.edu | EPIDNWG | UNSPECIFIED |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Center for Aging and Population Health |
| Date: |
18 December 2024 |
| Date Type: |
Completion |
| Number of Pages: |
55 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Public Health > Epidemiology |
| Degree: |
MPH - Master of Public Health |
| Thesis Type: |
Master Essay |
| Refereed: |
Yes |
| Date Deposited: |
18 Dec 2024 19:33 |
| Last Modified: |
18 Dec 2024 19:33 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/47203 |
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