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Development of Small Molecule and Antibody Adaptors for Programming of Universal CAR T Cells

Falcone, Gianna Ninetta (2024) Development of Small Molecule and Antibody Adaptors for Programming of Universal CAR T Cells. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

The field of immunotherapy has grown drastically since the introduction of CAR T cell therapy, which is introduced in Chapter 1.0. Methods of conditional control to reduce off-target toxicities associated with CAR T cell therapy are discussed in Chapter 2.0. Additionally, the SNAP-CAR system, developed by the Deiters and Lohmueller labs, is introduced and further explored in Chapter 3.0. In Chapter 3.2, site-specific antibody conjugation is utilized and compared directly to previous adaptors made via heterogeneous modification. Additional advantages of these site-specific adaptors are discussed in the context of ADEPT as a therapeutic in Chapter 5.0. As an alternative to using antibodies to target antigens on cancer cells, small molecule adaptors are explored as targeting ligands in Chapter 4.0.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Falcone, Gianna Ninettagnf7@pitt.edugnf7
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairDeiters, Alexanderalexdeiters@gmail.com
Committee MemberFloreancig, Paulflorean@pitt.edu
Committee MemberChilders, Seth W.wschild@pitt.edu
Committee MemberLohmueller, Jasonjasonloh@pitt.edu
Date: 20 December 2024
Date Type: Publication
Defense Date: 29 October 2024
Approval Date: 20 December 2024
Submission Date: 6 December 2024
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 185
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Antibody Conjugation, SNAP-CAR, CAR T cells, benzylguanine, acetazolamide, ADEPT
Date Deposited: 20 Dec 2024 14:04
Last Modified: 20 Dec 2024 14:04
URI: http://d-scholarship.pitt.edu/id/eprint/47235

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