Ricordi, C and Tzakis, AG and Carroll, PB and Zeng, Y and Rodriguez Rilo, HL and Alejandro, R and Shapiro, R and Fung, JJ and Demetris, AJ and Mintz, DH and Starzl, TE
(1992)
Human islet isolation and allotransplantation in 22 consecutive cases.
Transplantation, 53 (2).
407 - 414.
ISSN 0041-1337
Abstract
This report provides our initial experience in islet isolation and intrahepatic allotransplantation in 21 patients. In group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer. In group 2, 4 patients received a combined liver-islet allograft for cirrhosis and diabetes. One patient had plasma C-peptide >3 pM and was therefore excluded from analysis. In group 3, 7 patients received 8 combined cadaveric kidney-islet grafts (one retransplant) for end-stage renal disease secondary to type 1 diabetes mellitus. The islets were separated by a modification of the automated method for human islet isolation and the preparations were infused into the portal vein. Immunosuppression was with FK506 (group 1) plus steroids (groups 2 and 3). Six patients in group 1 did not require insulin treatment for 5 to > 16 months. In groups 2 and 3 none of the patients became insulin-independent, although decreased insulin requirement and stabilization of diabetes were observed. Our results indicate that rejection is still a major factor limiting the clinical application of islet transplantation in patients with type 1 diabetes mellitus, although other factors such as steroid treatment may contribute to deteriorate islet engraftment and/or function. © 1992 by Williams and Wilkins.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Ricordi, C | | | | | Tzakis, AG | | | | | Carroll, PB | | | | | Zeng, Y | | | | | Rodriguez Rilo, HL | | | | | Alejandro, R | | | | | Shapiro, R | | | | | Fung, JJ | | | | | Demetris, AJ | | | | | Mintz, DH | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1992 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Transplantation |
| Volume: |
53 |
| Number: |
2 |
| Page Range: |
407 - 414 |
| DOI or Unique Handle: |
10.1097/00007890-199202010-00027 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0041-1337 |
| Other ID: |
uls-drl:31735062111350, Starzl CV No. 1340 |
| Date Deposited: |
08 Apr 2010 17:22 |
| Last Modified: |
01 Jul 2018 01:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/4726 |
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