Starzl, TE and Demetris, AJ and Trucco, M and Zeevi, A and Ramos, H and Terasaki, P and Rudert, WA and Kocova, M and Ricordi, C and Ildstad, S and Murase, N
(1993)
Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation.
Transplantation, 55 (6).
1272 - 1277.
ISSN 0041-1337
Abstract
Chimerism was demonstrated with immunocytochemical and/or polymerase chain reaction techniques in kidney allografts and in the native skin, lymph nodes, or blood of 5 of 5 patients who received continuously functioning renal transplants from 1 or 2 haplotype HLA mismatched consanguineous donors (4 parents, 1 aunt) 27-29 years ago. In the 4 cases where the kidney donor still was alive to provide stimulator lymphocytes for testing, these provoked no (n=2) or modest (n=2) MLR in contrast to vigorous MLR to third party lymphocytes. In all 4 cases, the donor cells failed to generate in vitro cytotoxic effector cells (cell-mediated lymphocytotoxicity). These findings are in accord with the hypothesis that cell migration, repopulation, and chimerism are seminal events that define graft acceptance and ultimately can lead to acquired donor-specific nonresponsiveness (tolerance). © 1993 Williams and wilkins.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Starzl, TE | tes11@pitt.edu | TES11 | | Demetris, AJ | | | | Trucco, M | mnt@pitt.edu | MNT | | Zeevi, A | | | | Ramos, H | | | | Terasaki, P | | | | Rudert, WA | | | | Kocova, M | | | | Ricordi, C | | | | Ildstad, S | | | | Murase, N | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1 January 1993 |
Date Type: |
Publication |
Journal or Publication Title: |
Transplantation |
Volume: |
55 |
Number: |
6 |
Page Range: |
1272 - 1277 |
DOI or Unique Handle: |
10.1097/00007890-199306000-00012 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0041-1337 |
Other ID: |
uls-drl:31735062112358, Starzl CV No. 1444 |
Date Deposited: |
08 Apr 2010 17:24 |
Last Modified: |
03 Aug 2020 14:56 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/4830 |
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