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Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation

Starzl, TE and Demetris, AJ and Trucco, M and Zeevi, A and Ramos, H and Terasaki, P and Rudert, WA and Kocova, M and Ricordi, C and Ildstad, S and Murase, N (1993) Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation, 55 (6). 1272 - 1277. ISSN 0041-1337

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Abstract

Chimerism was demonstrated with immunocytochemical and/or polymerase chain reaction techniques in kidney allografts and in the native skin, lymph nodes, or blood of 5 of 5 patients who received continuously functioning renal transplants from 1 or 2 haplotype HLA mismatched consanguineous donors (4 parents, 1 aunt) 27-29 years ago. In the 4 cases where the kidney donor still was alive to provide stimulator lymphocytes for testing, these provoked no (n=2) or modest (n=2) MLR in contrast to vigorous MLR to third party lymphocytes. In all 4 cases, the donor cells failed to generate in vitro cytotoxic effector cells (cell-mediated lymphocytotoxicity). These findings are in accord with the hypothesis that cell migration, repopulation, and chimerism are seminal events that define graft acceptance and ultimately can lead to acquired donor-specific nonresponsiveness (tolerance). © 1993 Williams and wilkins.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Demetris, AJ
Trucco, Mmnt@pitt.eduMNT
Zeevi, A
Ramos, H
Terasaki, P
Rudert, WA
Kocova, M
Ricordi, C
Ildstad, S
Murase, N
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1993
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 55
Number: 6
Page Range: 1272 - 1277
DOI or Unique Handle: 10.1097/00007890-199306000-00012
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062112358, Starzl CV No. 1444
Date Deposited: 08 Apr 2010 17:24
Last Modified: 03 Aug 2020 14:56
URI: http://d-scholarship.pitt.edu/id/eprint/4830

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