Madariaga, JR and Marino, IR and Karavias, DD and Nalesnik, MA and Doyle, HR and Iwatsuki, S and Fung, JJ and Starzl, TE
(1995)
Long-term results after liver transplantation for primary hepatic epithelioid hemangioendothelioma.
Annals of Surgical Oncology, 2 (6).
483 - 487.
ISSN 1068-9265
Abstract
Background: Hepatic epithelioid hemangioendothelioma (PHEHE) is a multifocal, low-grade malignant neoplasia characterized by its epithelial-like appearance and vascular endothelial histogenesis. The outcome of 16 patients treated with orthotopic liver transplantation (OLT) is the subject of this report. Methods: A retrospective study of 16 patients with HEHE (7 men, 9 women) with ages ranging from 24 to 58 years (mean 37 ± 10.6 years). Follow-up intervals ranged from 1 to 15 years (median of 4.5 years). Results: Actual patient survival at 1, 3, and 5 years was 100, 87.5, and 71.3%, respectively. Disease-free survival at 1, 3, and 5 years was 81.3, 68.8, and 60.2%, respectively. The 90-day operative mortality was 0. Involvement of the hilar lymph nodes or vascular invasion did not affect survival. The 5-year survival of HEHE compares favorably with that of hepatocellular carcinoma at the same stage (stage 4A): 71.3 versus 9.8% (p=0.001) Conclusions: The long-term survival obtained in this series justifies OLT for these tumors even in the presence of limited extrahepatic disease. © 1995 The Society of Surgical Oncology, Inc.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Madariaga, JR | | | | | Marino, IR | | | | | Karavias, DD | | | | | Nalesnik, MA | nalesnik@pitt.edu | NALESNIK | | | Doyle, HR | | | | | Iwatsuki, S | | | | | Fung, JJ | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 November 1995 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Annals of Surgical Oncology |
| Volume: |
2 |
| Number: |
6 |
| Page Range: |
483 - 487 |
| DOI or Unique Handle: |
10.1007/bf02307080 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
1068-9265 |
| Other ID: |
uls-drl:31735062125178, Starzl CV No. 1667 |
| Date Deposited: |
08 Apr 2010 17:28 |
| Last Modified: |
29 Jan 2019 15:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/5053 |
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