Prevention of transplant rejection can tolerance be achieved with immunosuppressive treatment?

Delaney, CP and Murase, N and Starzl, TE and Demetris, AJ (1996) Prevention of transplant rejection can tolerance be achieved with immunosuppressive treatment? Clinical Immunotherapeutics, 6 (2). 89 - 96. ISSN 1172-7039

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Abstract

Successful solid organ transplantation is generally attributed to the increasingly precise ability of drugs to control rejection. However, it was recently shown that a few donor haematolymphoid cells can survive for decades in recipients of successful organ allografts, a phenomenon called microchimaerism. The association for decades of haematolymphoid chimaerism with allograft tolerance in experimental transplantation suggests that immunosuppressive drugs merely create a milieu that enables an allograft and its complement of passenger leucocytes to prime the recipient for graft acceptance. Exploitation of this concept requires a fundamental shift in the classical view of passenger leucocytes only as initiators of rejection. Microchimaerism has taught us that solid organ transplantation involves the transfep-öTEwo3öTK}r organ systems to the recipient: the allograft parenchyma an-4oHg-4oonor'-4y&eWtolymphoid system in the form of donor stem cells contajfletwit|4Q(Xj pas-4MTger leucocyte compartment. Each has the potential to integral witty-4-4orrespSnping recipient system and carry out normal physiologi|:a£futy-4ijj£jvwlta5irnmunological self definition. Resistance to initial integralen r-4WMjure £als requires some form of immunosuppression, but mainterçad-4 of donor-4Rjraiine system function will depend on renewable supply of cells, v-4Jrf-4Siyi-4jj-4fvided by engrafted progenitors. Successful clinical application willctepcrrtTon the development of low morbidity methods to enhance engraftment of donor haemopoietic stem cells. Adis international Limited All rights reserved.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Delaney, CP Murase, N Starzl, TE tes11@pitt.edu TES11 Demetris, AJ
Centers:	Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date:	1 January 1996
Date Type:	Publication
Journal or Publication Title:	Clinical Immunotherapeutics
Volume:	6
Number:	2
Page Range:	89 - 96
DOI or Unique Handle:	10.1007/bf03259505
Institution:	University of Pittsburgh
Refereed:	Yes
ISSN:	1172-7039
Other ID:	uls-drl:31735062133594, Starzl CV No. 1894
Date Deposited:	08 Apr 2010 17:32
Last Modified:	27 Jan 2019 02:55
URI:	http://d-scholarship.pitt.edu/id/eprint/5280

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