Casavilla, EA and Rakela, J and Kapur, S and Irish, W and McMichael, J and Demetris, AJ and Starzl, TE and Fung, JJ
(1998)
Clinical outcome of patients infected with hepatitis C virus infection on survival after primary liver transplantation under tacrolimus.
Liver Transplantation and Surgery, 4 (6).
448 - 454.
ISSN 1074-3022
Abstract
The outcome of hepatitis C virus (HCV) infection on patient and graft survival after orthotopic liver transplantation (OLT) has been controversial. An earlier experience with a higher dose of tacrolimus (≥0.1 mg/kg/d intravenously and ≥0.2 mg/kg/d orally) was associated with a worse clinical outcome in patients infected with HCV. The clinical outcome of 183 liver transplant recipients with end-stage liver disease (ESLD) secondary to HCV infection (HCV group) was compared with a contemporary cohort of 556 patients with HCV infection who underwent transplantation for nonviral, nonmalignant ESLD (control group). All patients were prospectively screened for anti-HCV antibodies and HCV RNA by reverse-transcriptase polymerase chain reaction. All OLT patients were receiving low-dose tacrolimus immunosuppression. Cumulative patient survival rates for the HCV group were 80% after I year and 75% after 3 years compared with rates of 84% and 78%, respectively, in the control group (P = .452). Primary graft survival rates at the same time intervals for the HCV group and the control group were 72% and 77.5% at 1 year and 67% and 72% at 3 years, respectively (P = .144). The incidence of re-transplantation (re-OLT) in the HCV group and the control group was 12.6% and 10.4%, respectively (P = .42). Chronic HCV infection as an indication for OLT with a lower dose of tacrolimus immunosuppression (≤0.05 mg/kg/d intravenously and ≤0.1 mg/kg/d orally) is associated with a similar patient and graft survival as those without HCV infection.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Casavilla, EA | | | | | Rakela, J | | | | | Kapur, S | | | | | Irish, W | | | | | McMichael, J | | | | | Demetris, AJ | | | | | Starzl, TE | tes11@pitt.edu | TES11 | | | Fung, JJ | | | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1998 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Liver Transplantation and Surgery |
| Volume: |
4 |
| Number: |
6 |
| Page Range: |
448 - 454 |
| DOI or Unique Handle: |
10.1002/lt.500040605 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
1074-3022 |
| Other ID: |
uls-drl:31735062127778, Starzl CV No. 2056 |
| Date Deposited: |
08 Apr 2010 17:35 |
| Last Modified: |
27 Jan 2019 02:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/5442 |
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