Chen, G and Qian, H and Starzl, T and Sun, H and Garcia, B and Wang, X and Wise, Y and Liu, Y and Xiang, Y and Copeman, L and Liu, W and Jevnikar, A and Wall, W and Cooper, DKC and Murase, N and Dai, Y and Wang, W and Xiong, Y and White, DJ and Zhong, R
(2005)
Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.
Nature Medicine, 11 (12).
1295 - 1298.
ISSN 1078-8956
Abstract
We transplanted kidneys from α1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans. © 2005 Nature Publishing Group.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Chen, G | | | | Qian, H | | | | Starzl, T | tes11@pitt.edu | TES11 | | Sun, H | | | | Garcia, B | | | | Wang, X | | | | Wise, Y | | | | Liu, Y | | | | Xiang, Y | | | | Copeman, L | | | | Liu, W | | | | Jevnikar, A | | | | Wall, W | | | | Cooper, DKC | | | | Murase, N | | | | Dai, Y | | | | Wang, W | | | | Xiong, Y | | | | White, DJ | | | | Zhong, R | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1 December 2005 |
Date Type: |
Publication |
Journal or Publication Title: |
Nature Medicine |
Volume: |
11 |
Number: |
12 |
Page Range: |
1295 - 1298 |
DOI or Unique Handle: |
10.1038/nm1330 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
1078-8956 |
Other ID: |
uls-drl:31735062121318, Starzl CV No. 2221 |
Date Deposited: |
08 Apr 2010 17:38 |
Last Modified: |
05 Feb 2019 15:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/5607 |
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