Using primary afferent neural activity for predicting limb kinematics in cat

Wagenaar, Joost Bastiaan (2011) Using primary afferent neural activity for predicting limb kinematics in cat. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

Kinematic state feedback is important for neuroprostheses to generate stable and adaptive movements of an extremity. State information, represented in the firing rates of populations of primary afferent neurons, can be recorded at the level of the dorsal root ganglia (DRG). Previous work in cats showed the feasibility of using DRG recordings to predict the kinematic state of the hind limb using reverse regression. Although accurate decoding results were attained, these methods did not make efficient use of the information embedded in the firing rates of the neural population. This dissertation proposes new methods for decoding limb kinematics from primary afferent firing rates. We present decoding results based on state-space modeling, and show that it is a more principled and more efficient method for decoding the firing rates in an ensemble of primary afferent neurons. In particular, we show that we can extract confounded information from neurons that respond to multiple kinematic parameters, and that including velocity components in the firing rate models significantly increases the accuracy of the decoded trajectory. This thesis further explores the feasibility of decoding primary afferent firing rates in the presence of stimulation artifact generated during functional electrical stimulation. We show that kinematic information extracted from the firing rates of primary afferent neurons can be used in a 'real-time' application as a feedback for control of FES in a neuroprostheses. It provides methods for decoding primary afferent neurons and sets a foundation for further development of closed loop FES control of paralyzed extremities. Although a complete closed loop neuroprosthesis for natural behavior seems far away, the premise of this work argues that an interface at the dorsal root ganglia should be considered as a viable option.

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Details

Item Type:	University of Pittsburgh ETD
Status:	Unpublished
Creators/Authors:	Creators Email Pitt Username ORCID Wagenaar, Joost Bastiaan jbw14@pitt.edu JBW14
ETD Committee:	Title Member Email Address Pitt Username ORCID Committee Chair Weber, D J djw50@pitt.edu DJW50 Committee Member Schwartz, A B abs21@pitt.edu ABS21 Committee Member Yates, B J byates@pitt.edu BYATES Committee Member Atkeson, C G cga@cs.cmu.edu Committee Member Ventura, V vventura@stat.cmu.edu
Date:	27 June 2011
Date Type:	Completion
Defense Date:	25 March 2011
Approval Date:	27 June 2011
Submission Date:	6 April 2011
Access Restriction:	No restriction; Release the ETD for access worldwide immediately.
Institution:	University of Pittsburgh
Schools and Programs:	Swanson School of Engineering > Bioengineering
Degree:	PhD - Doctor of Philosophy
Thesis Type:	Doctoral Dissertation
Refereed:	Yes
Uncontrolled Keywords:	bioengineering; closed loop control; FES; muscle spindle; nervous system; neuroprostheses; primary afferent; state-space modeling
Other ID:	http://etd.library.pitt.edu/ETD/available/etd-04062011-172800/, etd-04062011-172800
Date Deposited:	10 Nov 2011 19:34
Last Modified:	15 Nov 2016 13:38
URI:	http://d-scholarship.pitt.edu/id/eprint/6839

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