Morgan, Paul M
(2008)
Synthesis and NMR Strcuture Determination of Bis-Amino-Acid Oligomers.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
in chapters 2 and 3, I present the synthesis of three bis-amino acid monomers. The pro3 class of monomers were designed to create a sharp turn in a bis-amino acid oligomeric sequences. The pro3(2S4S) monomer was synthesised, but had an unexpected tendency to epimerize when incorporated into an oligomer. The syntheses of two pip5 class monomers were completed in 13% overall yield and 21% overall yield.In the fourth chapter, I present the first use of residual dipolar coupling (RDC)measurement in the solution structure determination of a bis-amino-aicd oligomer. This technique allows the determination of bond orientations within a molecule with respect to the magnetic field of a nuclear magnetic resonance (NMR)spectrometer. I determined that the information gained from the measurement of RDCs can be used to filter a library of conformational models to select the best fit model to the RDC data. The best fit model was found to ve the lowest energy conformation of the bis-amino acid oligomer.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
| Title | Member | Email Address | Pitt Username | ORCID |
|---|
| Committee Chair | Schafmeister, Christian | meister@pitt.edu | MEISTER | | | Committee Member | Gronenborn, Angela | | | | | Committee Member | Spence, Megan | | | | | Committee Member | Floreancig, Paul | | | |
|
| Date: |
28 January 2008 |
| Date Type: |
Completion |
| Defense Date: |
8 August 2006 |
| Approval Date: |
28 January 2008 |
| Submission Date: |
6 August 2007 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Bis-Amino acid; NMR; residual dipolar coupling |
| Other ID: |
http://etd.library.pitt.edu/ETD/available/etd-08062007-085555/, etd-08062007-085555 |
| Date Deposited: |
10 Nov 2011 19:57 |
| Last Modified: |
15 Nov 2016 13:48 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/8929 |
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