Tarbox, Sarah Irene
(2010)
The Nature of Schizotypy among Multigenerational Multiplex Schizophrenia Families.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
Identification of endophenotypes (I. I. Gottesman & Gould, 2003; I. I. Gottesman & Shields, 1972)] that correlate with familial liability to schizophrenia and are maximally sensitive to a homogeneous subset of risk genes is an important strategy for detecting genes that affect schizophrenia risk. Symptoms of schizotypy may correlate with familial liability to schizophrenia; however, there are critical limitations of the current literature concerning this association. The present study examined the genetic architecture and genetic association between schizotypy and genetic liability to schizophrenia among multigenerational, multiplex schizophrenia families. Genetic schizotypy factors were identified that significantly correlated with genetic liability to schizophrenia, although some relations were unexpected in direction. These genetic factors did not correlate with genetic liability to major depressive disorder or substance dependence. Results suggest that genetic schizotypy factors may have the potential to be particularly useful endophenotypes in genetic linkage analyses of schizophrenia.
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Details
Item Type: |
University of Pittsburgh ETD
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Status: |
Unpublished |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Tarbox, Sarah Irene | sat7@pitt.edu | SAT7 | |
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ETD Committee: |
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Date: |
1 October 2010 |
Date Type: |
Completion |
Defense Date: |
8 September 2009 |
Approval Date: |
1 October 2010 |
Submission Date: |
18 August 2010 |
Access Restriction: |
5 year -- Restrict access to University of Pittsburgh for a period of 5 years. |
Institution: |
University of Pittsburgh |
Schools and Programs: |
Dietrich School of Arts and Sciences > Psychology |
Degree: |
PhD - Doctor of Philosophy |
Thesis Type: |
Doctoral Dissertation |
Refereed: |
Yes |
Uncontrolled Keywords: |
genetic factor analysis; phenotype; relatives; schizotypal personality disorder; social functioning |
Other ID: |
http://etd.library.pitt.edu/ETD/available/etd-08182010-005710/, etd-08182010-005710 |
Date Deposited: |
10 Nov 2011 20:00 |
Last Modified: |
19 Dec 2016 14:37 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/9179 |
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